Associations between Mycobacterium tuberculosis Strains and Phenotypes
Timothy Brown1, Vladyslav Nikolayevskyy1, Preya Velji, and Francis Drobniewski
Author affiliations: United Kingdom Health Protection Agency, London UK (T. Brown, F. Drobniewski); Queen Mary College, University of London, London (V. Nikolayevskyy, P. Velji, F. Drobniewski); 1These authors contributed equally to this article.
Figure 2. Maximum-parsimony tree constructed based on 3 independent sets of markers: large sequence polymorphisms (LSPs), single nucleotide polymorphisms (SNPs), and number of repeats in the locus 24 using the following assumptions: 1) SNPs are irreversible unique events; 2) LSPs are irreversible rare events; 3) spoligotypes are not produced by convergent events; and 4) variable number tandem repeat (VNTR) loci can both acquire and lose repeats. EAI, East African–Indian; MIRU, mycobacterial interspersed repetitive unit code; EuroAm, European American; CAS, Central Asian; MBOV, M. bovis; MAFR, M. africanum; BCG, bacillus Calmette-Guérin. The X, T, LAM, S, and Haarlem families are European American types.
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