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Volume 16, Number 2—February 2010

Research

Associations between Mycobacterium tuberculosis Strains and Phenotypes

Timothy Brown1, Vladyslav Nikolayevskyy1, Preya Velji, and Francis DrobniewskiComments to Author 
Author affiliations: United Kingdom Health Protection Agency, London UK (T. Brown, F. Drobniewski); Queen Mary College, University of London, London (V. Nikolayevskyy, P. Velji, F. Drobniewski); 1These authors contributed equally to this article.

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Table 4

Minimum number of unique types seen within each Mycobacterium tuberculosis spoligotype family, by resistance or susceptibility to 5 antimicrobial drugs, United Kingdom*

Spoligotype family No. types, by drug resistance or drug susceptibility
STR-R STR-S INH-R INH-S ETH-R ETH-S RIF-R RIF-S PZA-R PZA-S MDR+ MDR–
Beijing 10 40 13 38 3 43 5 43 1 45 5 45
CAS 14 202 30 198 1 206 3 206 2 206 3 206
EAI 8 244 23 234 3 247 4 247 1 248 4 247
European American 45 451 59 441 5 475 19 467 6 474 10 470
M. bovis BCG 0 6 2 4 1 5 1 5 2 3 1 5
Family 33–36 5 39 4 41 1 43 1 43 0 44 1 44
M. africanum 2 22 0 22 0 22 0 22 0 22 0 22

*STR, streptomycin; R, resistant; S, susceptible; INH, isoniazid; ETH, erythromycin; RIF, rifampin; PZA, pyrazinamide; MDR, multidrug-resistant; CAS, Central Asian; EAI, East African–Indian.

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