Volume 16, Number 3—March 2010
Dispatch
Experimental Infection of Squirrel Monkeys with Nipah Virus
Philippe Marianneau1, Vanessa Guillaume1, K. Thong Wong, Munisamy Badmanathan, Ren Yih Looi, Séverine Murri, Philippe Loth, Noël Tordo, T. Fabian Wild, Branka Horvat
, and Hugues Contamin
, and Hugues ContaminTable 1
Clinical course of Nipah virus infection in 12 squirrel monkeys*
| Monkey | Mode of infection | Dose, PFU/mL | Day of 1st symptoms | Duration of clinical state | Day of euthanasia | Clinical state at euthanasia | Clinical signs |
|---|---|---|---|---|---|---|---|
| A† | IV | 103 | – | – | 3 | Well | None |
| B | IV | 103 | 10 | 3 | 12† | Moribund | Uncoordinated motor movements, prostration and coma |
| C | IV | 103 | 19 | 3 | 21‡ | Moribund | Uncoordinated motor movements, prostration, and coma |
| D† | IV | 107 | – | – | 3 | Well | None |
| E | IV | 107 | 7 | 2 | 8† | Moribund | Uncoordinated motor movements, prostration, and coma |
| F | IV | 107 | 14 | 3 | 52 | Recovered/well | Anorexia, depression |
| G† | IN | 103 | – | – | 4 | Well | None |
| H | IN | 103 | – | – | 52 | Well | None |
| I | IN | 103 | 8 | 3 | 56 | Recovered/well | Anorexia, seizure |
| J† | IN | 107 | – | – | 4 | Well | None |
| K | IN | 107 | 17 | Septic shock not correlated with NiV infection | |||
| L | IN | 107 | 10 | 7 | 56 | Recovered/well | Anorexia, seizure, edema of eyes |
*IV, intravenous; IN, intranasal; NiV, Nipah virus.
†Early systematic euthanasia.
‡Death caused by NiV infection.
