Volume 16, Number 3—March 2010
Dispatch
Quinine-Resistant Malaria in Traveler Returning from Senegal, 2007
Bruno Pradines, Thierry Pistone, Khaled Ezzedine
, Sébastien Briolant, Lionel Bertaux, Marie-Catherine Receveur, Daniel Parzy, Pascal Millet, Christophe Rogier, and Denis Malvy
, Sébastien Briolant, Lionel Bertaux, Marie-Catherine Receveur, Daniel Parzy, Pascal Millet, Christophe Rogier, and Denis MalvyTable
In vitro susceptibility of 3 Plasmodium falciparum isolates to 12 antimalarial drugs, France*
| Drug | 50% Inhibitory concentration |
|||
|---|---|---|---|---|
| Study isolate | 3D7 | W2 | Cutoff value | |
| Quinine | 829 nmol/L | 157 nmol/L | 574 nmol/L | >800 nmol/L |
| Chloroquine | 472 nmol/L | 21 nmol/L | 392 nmol/L | >100 nmol/L |
| Mefloquine | 10.4 nmol/L | 49.3 nmol/L | 39.3 nmol/L | >30 nmol/L |
| Lumefantrine | 19 nmol/L | 29 nmol/L | 35 nmol/L | >150 nmol/L |
| Monodesethylamodiaquine | 47 nmol/L | 17 nmol/L | 162 nmol/L | >80 nmol/L |
| Dihydroartemisinin | 1.1 nmol/L | 2.5 nmol/L | 3.0 nmol/L | >10.5 nmol/L |
| Atovaquone | 13.3 nmol/L | 4.1 nmol/L | 3.6 nmol/L | >350 nmol/L |
| Cycloguanil | 70 nmol/L | <10 nmol/L | 1191 nmol/L | >500 nmol/L |
| Pyrimethamine | 354 nmol/L | <50 nmol/L | 9139 nmol/L | >2,000 nmol/L |
| Doxycycline | 12.8 μmol/L | 10.5 μmol/L | 13.5 μmol/L | >35 μmol/L |
| Azithromycin | 24 μmol/L | 48 μmol/L | 39 μmol/L | ND |
| Clindamycin | 39 μmol/L | 108 μmol/L | 126 μmol/L | ND |
*P. falciparum strains 3D7 and W2 were used as controls. ND, not determined.
