Emerging Infectious Disease ISSN: 1080-6059

Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice

Mutien-Marie Garigliany, Adélite Habyarimana, Bénédicte Lambrecht, Els Van de Paar, Anne Cornet, Thierry van den Berg, and Daniel Desmecht

Author affiliations: University of Liège, Liège, Belgium (M.-M. Garigliany, E. Van de Paar, A. Cornet, D. Desmecht); Veterinary Agrochemical Center, Brussels, Belgium (A. Habyarimana, B. Lambrecht, T. van den Berg).

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Figure 2

Effect of influenza A virus subtype H5N1 and H1N1 strains on lung weight after intranasal inoculation of 10× the 50% mouse lethal dose on day 0. Absolute values are given as means ± SD for 5 mice at each time point. For each virus strain, means significantly different from those of control (CTL) lungs are indicated (nonparametric Mann-Whitney test). *p<0.05; †p<0.01.

Figure 2. Effect of influenza A virus subtype H5N1 and H1N1 strains on lung weight after intranasal inoculation of 10× the 50% mouse lethal dose on day 0. Absolute values are given as means ± SD for 5 mice at each time point. For each virus strain, means significantly different from those of control (CTL) lungs are indicated (nonparametric Mann-Whitney test). *p<0.05; †p<0.01.

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