Emerging Infectious Disease ISSN: 1080-6059

Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice

Mutien-Marie Garigliany, Adélite Habyarimana, Bénédicte Lambrecht, Els Van de Paar, Anne Cornet, Thierry van den Berg, and Daniel Desmecht

Author affiliations: University of Liège, Liège, Belgium (M.-M. Garigliany, E. Van de Paar, A. Cornet, D. Desmecht); Veterinary Agrochemical Center, Brussels, Belgium (A. Habyarimana, B. Lambrecht, T. van den Berg).

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Figure 3

Effect of influenza A virus subtype strains H5N1 and H1N1 on lung virus titers 2–8 days after intranasal inoculation of 10× the 50% mouse lethal dose on day 0. Titers are expressed as the log10 median tissue culture infectious dose (TCID50) units per milliliter of lung homogenate. Significantly different titers are indicated (nonparametric Mann-Whitney test). Error bars indicate SD calculated from individual virus titers. *p <0.05.

Figure 3. Effect of influenza A virus subtype strains H5N1 and H1N1 on lung virus titers 2–8 days after intranasal inoculation of 10× the 50% mouse lethal dose on day 0. Titers are expressed as the log₁₀ median tissue culture infectious dose (TCID₅₀) units per milliliter of lung homogenate. Significantly different titers are indicated (nonparametric Mann-Whitney test). Error bars indicate SD calculated from individual virus titers. *p <0.05.

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