Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice
Mutien-Marie Garigliany, Adélite Habyarimana, Bénédicte Lambrecht, Els Van de Paar, Anne Cornet, Thierry van den Berg, and Daniel Desmecht
Author affiliations: University of Liège, Liège, Belgium (M.-M. Garigliany, E. Van de Paar, A. Cornet, D. Desmecht); Veterinary Agrochemical Center, Brussels, Belgium (A. Habyarimana, B. Lambrecht, T. van den Berg).
Figure 5. Photomicrographs of liver, spleen, and lung sections from influenza virus A (H5N1)–infected mice at endpoint. Necrotic foci (arrows) scattered throughout the liver (A) (original magnification ×200) and spleen (B) (original magnification ×100) from subtype H5N1–infected mice (hematoxylin and eosin stain); these foci are absent from subtype H1N1–infected mouse livers. C) Necrotic foci in the liver stain periodic acid–Schiff (PAS)–positive (arrow), which suggests focal accumulation of glycogen (original magnification ×400). D) Numerous alveolar walls lined with PAS-stained hyaline membranes (arrows), suggestive of necrosis and desquamation of pneumocytes (original magnification ×1,000).
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.