Volume 16, Number 6—June 2010
Research
Clonal Expansion of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, Japan
Yoshiro Murase
, Shinji Maeda, Hiroyuki Yamada, Akihiro Ohkado, Kinuyo Chikamatsu, Kazue Mizuno, Seiya Kato, and Satoshi Mitarai
, Shinji Maeda, Hiroyuki Yamada, Akihiro Ohkado, Kinuyo Chikamatsu, Kazue Mizuno, Seiya Kato, and Satoshi MitaraiTable 4
Comparison of MDR/XDR TB patients and bacteriologic characteristics between clustered and nonclustered cases by IS6110-RFLP, Japan*
| Characteristic | No. (%) cases |
Odds ratio (95% confidence interval) |
||
|---|---|---|---|---|
| Clustered, n = 21 | Unique, n = 34 | Clustered vs. unique | ||
| Age, y | ||||
| 0–20 | 1 (5) | 0 | – | |
| 21–40 | 8 (38) | 12 (35) | 0.96 (0.23–3.95) | |
| 41–60 | 9 (43) | 13 (38) | 1 | |
| >61 |
3 (14) |
9 (26) |
0.48 (0.08–2.83) |
|
| Sex | ||||
| M | 12 (57) | 27 (79) | 1 | |
| F |
9 (43) |
7 (21) |
2.89 (0.75–11.45) |
|
| Nationality | ||||
| Japanese | 19 (90) | 28 (82) | 1 | |
| Foreigner |
2 (10) |
6 (18) |
0.49 (0.06–3.18) |
|
| Treatment history | ||||
| New | 8 (38) | 8 (24) | 1 | |
| Previous |
13 (62) |
26 (76) |
0.50 (0.13–1.90) |
|
| Site of TB | ||||
| Pulmonary | 21 (100) | 34 (100) | – | |
| Extrapulmonary |
0 |
0 |
– |
|
| Chest radiograph finding | ||||
| Noncavitary | 6 (29) | 7 (21) | 1 | |
| Cavitary |
15 (71) |
27 (79) |
0.65 (0.15–2.71) |
|
| Sputum smear test result | ||||
| Negative | 4 (19) | 5 (15) | 1 | |
| Positive |
17 (81) |
29 (85) |
0.73 (0.14–3.86) |
|
| Complication | ||||
| None | 9 (43) | 18 (53) | 1 | |
| Diabetes mellitus | 5 (24) | 6 (18) | 1.67 (0.32–8.78) | |
| Malignancy |
2 (10) |
3 (9) |
1.33 (0.13–12.94) |
|
| XDR TB | ||||
| No | 9 (43) | 29 (85) | 1 | |
| Yes |
12 (57) |
5 (15) |
7.73 (1.84–34.83) |
|
| Beijing family genotype | ||||
| No | 6 (29) | 15 (44) | 1 | |
| Yes | 15 (71) | 19 (56) | 1.97 (0.57–7.46) | |
*MDR, multidrug-resistant; XDR, extensively drug-resistant; TB, tuberculosis; IS6110-RFLP, insertion sequence 6110 restriction fragment length polymorphism –, not available. Boldface indicates significance.
