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Volume 16, Number 6—June 2010

Research

Clonal Expansion of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, Japan

Yoshiro MuraseComments to Author , Shinji Maeda, Hiroyuki Yamada, Akihiro Ohkado, Kinuyo Chikamatsu, Kazue Mizuno, Seiya Kato, and Satoshi Mitarai
Author affiliations: The Research Institute of Tuberculosis/Japan Anti-Tuberculosis Association, Tokyo, Japan

Main Article

Table 4

Comparison of MDR/XDR TB patients and bacteriologic characteristics between clustered and nonclustered cases by IS6110-RFLP, Japan*

Characteristic No. (%) cases
Odds ratio (95% confidence interval)
Clustered, n = 21 Unique, n = 34 Clustered vs. unique
Age, y
0–20 1 (5) 0
21–40 8 (38) 12 (35) 0.96 (0.23–3.95)
41–60 9 (43) 13 (38) 1
>61
3 (14)
9 (26)

0.48 (0.08–2.83)
Sex
M 12 (57) 27 (79) 1
F
9 (43)
7 (21)

2.89 (0.75–11.45)
Nationality
Japanese 19 (90) 28 (82) 1
Foreigner
2 (10)
6 (18)

0.49 (0.06–3.18)
Treatment history
New 8 (38) 8 (24) 1
Previous
13 (62)
26 (76)

0.50 (0.13–1.90)
Site of TB
Pulmonary 21 (100) 34 (100)
Extrapulmonary
0
0


Chest radiograph finding
Noncavitary 6 (29) 7 (21) 1
Cavitary
15 (71)
27 (79)

0.65 (0.15–2.71)
Sputum smear test result
Negative 4 (19) 5 (15) 1
Positive
17 (81)
29 (85)

0.73 (0.14–3.86)
Complication
None 9 (43) 18 (53) 1
Diabetes mellitus 5 (24) 6 (18) 1.67 (0.32–8.78)
Malignancy
2 (10)
3 (9)

1.33 (0.13–12.94)
XDR TB
No 9 (43) 29 (85) 1
Yes
12 (57)
5 (15)

7.73 (1.8434.83)
Beijing family genotype
No 6 (29) 15 (44) 1
Yes 15 (71) 19 (56) 1.97 (0.57–7.46)

*MDR, multidrug-resistant; XDR, extensively drug-resistant; TB, tuberculosis; IS6110-RFLP, insertion sequence 6110 restriction fragment length polymorphism –, not available. Boldface indicates significance.

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