Volume 16, Number 7—July 2010
Research
High Diversity and Ancient Common Ancestry of Lymphocytic Choriomeningitis Virus
Cesar G. Albariño1
, Gustavo Palacios1, Marina L. Khristova, Bobbie R. Erickson, Serena A. Carroll, James A. Comer, Jeffrey Hui, Thomas Briese, Kirsten St. George, Thomas G. Ksiazek2, W. Ian Lipkin, and Stuart T. Nichol
, Gustavo Palacios1, Marina L. Khristova, Bobbie R. Erickson, Serena A. Carroll, James A. Comer, Jeffrey Hui, Thomas Briese, Kirsten St. George, Thomas G. Ksiazek2, W. Ian Lipkin, and Stuart T. NicholTable 2
Genetic diversity of lymphocytic choriomeningitis virus strains*
| Diversity | RNA, nt |
Proteins, aa |
|||||
|---|---|---|---|---|---|---|---|
| L | S | Z | L | GPC | N | ||
| Overall | 22 | 19 | 18 | 13 | 10 | 6 | |
| Within lineage I | 19 | 15 | 15 | 11 | 6 | 4 | |
| Within lineage II | 25 | 15 | 34 | 18 | 7 | 3 | |
| Within lineage III† | NA | NA | NA | NA | NA | NA | |
| Within lineage IV‡ | NA | 18 | NA | NA | 13 | 5 | |
| Between lineages I and II | 27 | 22 | 27 | 19 | 11 | 6 | |
| Between lineages I and III | 28 | 23 | 19 | 19 | 11 | 8 | |
| Between lineages I and IV | NA | 24 | NA | NA | 19 | 9 | |
| Between lineages II and III | 27 | 22 | 28 | 19 | 11 | 6 | |
| Between lineages II and IV | NA | 24 | NA | NA | 18 | 10 | |
| Between lineages III and IV | NA | 25 | NA | NA | 19 | 11 | |
*nt, nucleotide; aa, amino acid; GPC, glycoprotein precursor; NA, not applicable. Pairwise genetic distances (uncorrected p values) were measured eliminating all positions containing alignment gaps and missing data.
†Only 1 sequence in lineage III.
‡No available L sequence in lineage IV.
