Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 16, Number 7—July 2010
Dispatch

Postexposure Treatment of Marburg Virus Infection

Thomas W. GeisbertComments to Author , Lisa E. Hensley, Joan B. Geisbert, Anders Leung, Joshua C. Johnson, Allen Grolla, and Heinz Feldmann
Author affiliations: National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, USA (T.W. Geisbert, J.B. Geisbert); US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA (L.E. Hensley, J.C. Johnson); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (A. Leung, A. Grolla); National Institutes of Health, Hamilton, Montana, USA (H. Feldmann)

Main Article

Table 1

Viral load in rhesus monkeys after Marburg virus challenge*

Animal no. Group Treatment Time of treatment after challenge, h Plasma†
PBMC
Day 6 Day 10 Day 14 Day 6 Day 10 Day 14
1 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (+) NT
2 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (+) NT (–)
3 Exp 1 VSV-Marburg 24 3.76 (–) 6.19 (+) NT (–) NT (+)
4 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (–) NT (–)
5 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (–) NT (–)
6 Exp 1 VSV-Marburg 24 0 (–) 0 (–) 0 (–) NT (–) NT (–) NT (–)
Control 1 Cont 1 VSV-Lassa 24 3.76 (–) 7.33 (+) NT (–) NT (+)
7 Exp 2 VSV-Marburg 48 0 (–) 4.20 (+) 0 (–) NT (+) NT (+) NT (–)
8 Exp 2 VSV-Marburg 48 0 (–) 7.27 (+) NT (+) NT (+)
9 Exp 2 VSV-Marburg 48 3.76 (–) 7.25 (+) NT (+) NT (+)
10 Exp 2 VSV-Marburg 48 0 (–) 0 (–) 0 (–) NT (–) NT (–) NT (–)
11 Exp 2 VSV-Marburg 48 5.24 (+) 7.35 (+) NT (+) NT (+)
12 Exp 2 VSV-Marburg 48 3.76 (–) 6.81 (+) NT (–) NT (+)
Control 2 Cont 2 VSV-Lassa 48 4.05 (–) 7.24 (+) NT (+) NT (+)
Control 3 Cont 3 None NA 5.07 (+) 7.15 (+) NT (+) NT (+)

*PBMC, peripheral blood mononuclear cells; Exp, experimental; VSV, vesicular stomatitis virus; NT, not tested; Cont, control; (+), sample positive for Marburg virus by reverse transcription–PCR (RT-PCR); (−), sample negative for Marburg virus by RT-PCR; NA, not applicable.
†Log10 PFU of Marburg virus per milliliter of plasma.

Main Article

Page created: March 02, 2011
Page updated: March 02, 2011
Page reviewed: March 02, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external