Volume 16, Number 7—July 2010
Dispatch
Postexposure Treatment of Marburg Virus Infection
Thomas W. Geisbert
, Lisa E. Hensley, Joan B. Geisbert, Anders Leung, Joshua C. Johnson, Allen Grolla, and Heinz Feldmann
, Lisa E. Hensley, Joan B. Geisbert, Anders Leung, Joshua C. Johnson, Allen Grolla, and Heinz FeldmannTable 1
Viral load in rhesus monkeys after Marburg virus challenge*
| Animal no. | Group | Treatment | Time of treatment after challenge, h | Plasma† |
PBMC |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 6 | Day 10 | Day 14 | Day 6 | Day 10 | Day 14 | |||||
| 1 | Exp 1 | VSV-Marburg | 24 | 0 (–) | 0 (–) | 0 (–) | NT (–) | NT (+) | NT | |
| 2 | Exp 1 | VSV-Marburg | 24 | 0 (–) | 0 (–) | 0 (–) | NT (–) | NT (+) | NT (–) | |
| 3 | Exp 1 | VSV-Marburg | 24 | 3.76 (–) | 6.19 (+) | NT (–) | NT (+) | |||
| 4 | Exp 1 | VSV-Marburg | 24 | 0 (–) | 0 (–) | 0 (–) | NT (–) | NT (–) | NT (–) | |
| 5 | Exp 1 | VSV-Marburg | 24 | 0 (–) | 0 (–) | 0 (–) | NT (–) | NT (–) | NT (–) | |
| 6 | Exp 1 | VSV-Marburg | 24 | 0 (–) | 0 (–) | 0 (–) | NT (–) | NT (–) | NT (–) | |
| Control 1 | Cont 1 | VSV-Lassa | 24 | 3.76 (–) | 7.33 (+) | NT (–) | NT (+) | |||
| 7 | Exp 2 | VSV-Marburg | 48 | 0 (–) | 4.20 (+) | 0 (–) | NT (+) | NT (+) | NT (–) | |
| 8 | Exp 2 | VSV-Marburg | 48 | 0 (–) | 7.27 (+) | NT (+) | NT (+) | |||
| 9 | Exp 2 | VSV-Marburg | 48 | 3.76 (–) | 7.25 (+) | NT (+) | NT (+) | |||
| 10 | Exp 2 | VSV-Marburg | 48 | 0 (–) | 0 (–) | 0 (–) | NT (–) | NT (–) | NT (–) | |
| 11 | Exp 2 | VSV-Marburg | 48 | 5.24 (+) | 7.35 (+) | NT (+) | NT (+) | |||
| 12 | Exp 2 | VSV-Marburg | 48 | 3.76 (–) | 6.81 (+) | NT (–) | NT (+) | |||
| Control 2 | Cont 2 | VSV-Lassa | 48 | 4.05 (–) | 7.24 (+) | NT (+) | NT (+) | |||
| Control 3 | Cont 3 | None | NA | 5.07 (+) | 7.15 (+) | NT (+) | NT (+) | |||
*PBMC, peripheral blood mononuclear cells; Exp, experimental; VSV, vesicular stomatitis virus; NT, not tested; Cont, control; (+), sample positive for Marburg virus by reverse transcription–PCR (RT-PCR); (−), sample negative for Marburg virus by RT-PCR; NA, not applicable.
†Log10 PFU of Marburg virus per milliliter of plasma.
