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Volume 17, Number 1—January 2011
Letter

Class D OXA-48 Carbapenemase in Multidrug-Resistant Enterobacteria, Senegal

Olivier MoquetComments to Author , Coralie Bouchiat, Alfred Kinana, Abdoulaye Seck, Omar Arouna, Raymond Bercion, Sebastien Breurec, and Benoit Garin
Author affiliations: Author affiliations: Institut Pasteur, Dakar, Senegal (O. Moquet, C. Bouchiat, A. Kinana, A. Seck, S. Breurec, B. Garin); Hopital Principal, Dakar (O. Arouna, R. Bercion)

Main Article

Table

Resistance genes and carbapenem MICs of 11 Enterbacteriaceae isolates, Senegal, 2008–2009*

Isolate Species Origin† Resistance genes
MIC (µg/mL)
blaOXA-48 blaCTX-M-15 blaOXA-1 blaTEM aac-6′-Ib qnr tet dfr IPM MEM ERT
17176 Klebsiella pneumoniae 1 + + A,D 1 0.38 1.5
22184 K. pneumoniae 2 + + + + cr S A A1 1 0.38 1.5
20254 K. pneumoniae 3 + + + + cr S A A1 1 0.38 1.5
10243 K .pneumoniae 3 + + + + cr S A A1 1 0.38 1.5
19220 K. pneumoniae 2 + + + + cr B A,D 0.5 0.19 0.75
18212 K. pneumoniae 2 + 3 2 12
18220 K. pneumoniae 3 + + + S D 1 0.38 1.5
06003 K. pneumoniae 4 + 2 0.25 0.75
HPD Enterobacter cloacae 3 + + + + cr B,S B 4 3 8
20247 Enterobacter sakazakii 5 + + + + cr 0.5 1 3
24246 Escherichia coli 4 + + + cr S 2 0.5 2
J53 E. coli 0.12 0.03 0.03
TC E. coli + 0.5 0.19 0.75

*IPM, imipenem; MEM, meropenem; ERT, ertapenem; TC, transconjugants.
†Origin: 1, postsurgical visceral infection; 2, postsurgical orthopedic infection; 3, nosocomial urinary tract infection; 4, community-acquired urinary tract infection; 5, omphalocele infection.
‡Clonally related isolates.

Main Article

Page created: June 30, 2011
Page updated: June 30, 2011
Page reviewed: June 30, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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