Volume 17, Number 10—October 2011
Research
Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus Infection in England and Scotland, 2009–2010
, Angie Lackenby, Arlene Reynolds, Jim McMenamin, Nick F. Phin, Maria Zambon, and Richard G. Pebody
Table 1
Distribution and reported associations of age, sex, and underlying medical conditions of study case-patients and controls hospitalized for pandemic (H1N1) 2009, England and Scotland, April 27, 2009–April, 30, 2010*
| Patient characteristic | No. (%) case-patients, n = 34 | No. (%) controls, n = 346 | OR (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
| n | With characteristic | n | With characteristic | Crude | Adjusted† | |||
| Sex | ||||||||
| M | 34 | 23 (67.6) | 346 | 155 (44.8) | 0.4 (0.2–0.9) | 0.4 (0.2–1.2) | ||
| F | 34 | 11 (32.4) | 346 | 191 (55.2) | ||||
| Age group, y | ||||||||
| 0–4 | 34 | 4 (11.8) | 346 | 64 (18.5) | 1 | 1 | ||
| 5–14 | 34 | 4 (11.8) | 346 | 83 (23.9) | 0.8 (0.2–3.2) | 0.5 (0.1–3.4) | ||
| 15–24 | 34 | 1 (2.9) | 346 | 59 (17.1) | 0.3 (0.1–2.5) | 1 | ||
| 25–44 | 34 | 4 (11.8) | 346 | 74 (21.4) | 0.9 (0.2–3.6) | 0.5 (0.1–3.6) | ||
| 45–64 | 34 | 16 (47.1) | 346 | 56 (16.2) | 4.6 (1.4–14.5) | 2.4 (0.5–11.1) | ||
| >65 | 34 | 5 (14.7) | 346 | 10 (2.9) | 8.0 (1.8–34.9) | 4.1 (0.5–31.3) | ||
| Any underlying condition | 30 | 28 (93.3) | 278 | 164 (60.0) | 9.7(2.4–85.5) | |||
| Respiratory | 28 | 7 (25.0) | 284 | 94 (33.1) | 0.8 (0.3–2.1) | |||
| Cardiac | 28 | 3 (10.7) | 273 | 12 (4.4) | 3.0 (0.5–12.1) | |||
| Renal | 28 | 1 (3.6) | 275 | 11 (4.0) | 1.0 (0.0–7.4) | |||
| Liver | 28 | 3 (10.7) | 272 | 3 (1.1) | 12.2 (1.5–95.0) | |||
| Neurologic | 28 | 3 (10.7) | 269 | 15 (5.6) | 2.3 (0.4–9.1) | |||
| Immunosuppression | 28 | 21 (75.0) | 275 | 19 (6.9) | 35.4 (12.7–102.1) | 18.1 (6.6–49.9) | ||
| Diabetes | 28 | 4 (14.3) | 276 | 6 (2.2) | 9.0 (1.7–41.0) | |||
| Pregnancy | 28 | 0 | 301 | 19 (6.3) | ||||
| Other chronic disease | 28 | 6 (21.4) | 258 | 32 (12.4) | 2.5 (0.7–7.2) |
*Case-patients were those with osteltamivir-resistant pandemic (H1N1) 2009 strains; controls were those with osteltamir-sensitive pandemic (H1N1) 2009 strains. n indicates no. patients with information available for that category. OR, odds ratio; CI, confidence interval. | ||
*Case-patients were those with osteltamivir-resistant pandemic (H1N1) 2009 strains; controls were those with osteltamir-sensitive pandemic (H1N1) 2009 strains. n indicates no. patients with information available for that category. OR, odds ratio; CI, confidence interval.
†OR adjusted for age, sex, and underlying conditions (e.g., immunosuppression, chronic respiratory diseases).