Close Similarity between Sequences of Hepatitis E Virus Recovered from Humans and Swine, France, 2008−2009
Jérôme Bouquet, Sophie Tessé, Aurélie Lunazzi, Marc Eloit, Nicolas Rose, Elisabeth Nicand, and Nicole Pavio
Author affiliations: Anses, Laboratoire de Santé Animale, Maisons-Alfort, France (J. Bouquet, A. Lunazzi, N. Pavio); Hôpital des Armées Val de Grâce, Paris, France (S. Tessé, E. Nicand); Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort (M. Eloit); Anses, Laboratoire de Ploufragan-Plouzané, Ploufragan, France (N. Rose)
Figure 3. Phylogenetic tree of hepatitis E virus (HEV) detected in human and swine constructed by the neighbor-joining method with a bootstrap of 1,000 replicates based on the ClustalW alignment (MEGA4, www.megasoftware.net) of 204- to 306-nt sequences within open reading frame 2. The 106 HEV sequences recovered from patients from France are displayed as black dots (GenBank accession nos. JF730329−JF730434), the 43 HEV sequences recovered from swine from France are displayed as red dots (accession nos. JF718787−JF718829), and the 22 reference strains from GenBank are displayed as white dots (GenBank accession nos. in Table A1). Genotype 4, subtypes 3f, 3c, and 3e, as defined by Lu et al. (8), are encircled by a solid black line; undefined subtype is encircled by a dashed black line. Bootstrap values >70% are indicated on respective branches. Scale bar represents nucleotide substitutions per site.
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