Volume 17, Number 12—December 2011
A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults1
|Patient age, y/sex||Season||Influenza type||Previous conditions||Sudden death*||MBL2 haplotype†||MBL production haplotype‡||MBL2 structural variant|
*Sudden death is defined as death occurring less than 3 days after symptom onset. MBL2, mannose-binding lectin gene.
†Per common designation for MBL2, A refers to the wild-type structural allele, O refers to any of the 3 variant structural alleles, and O/O refers to any combination of structural variant alleles. Y refers to the wild-type allele and X to the variant allele at promoter locus rs7096206 (the X/Y variant).
‡Low mannose-binding lectin (MBL) producers included MBL2 haplotypes O/O and XA/O. Intermediate producers included MBL2 haplotypes XA/XA and YA/O. High producers included MBL2 haplotypes XA/YA and YA/YA.
1Portions of this study were presented at the Options for the Control of Influenza VII meeting, September 3–7, 2010, Hong Kong.