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Volume 17, Number 9—September 2011

Research

Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients

Fadi Al Akhrass, Ray Hachem, Jamal A. Mohamed, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis, Jyotsna Chandra, Mahmoud Ghannoum, Souha Haydoura, Ann Marie Chaftari, and Issam RaadComments to Author 
Author affiliations: Author affiliations: The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (F. Al Akhrass, R. Hachem, J.A. Mohamed, J. Tarrand, D.P. Kontoyiannis, A.M. Chaftari, I. Raad); Case Western Reserve University, Cleveland, Ohio, USA (J. Chandra, M. Ghannoum); University Hospitals Case Medical Center, Cleveland (J. Chandra, M. Ghannoum); Kansas University School of Medicine, Wichita, Kansas, USA (S. Haydoura)

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Figure 2

Antibiofilm agents inhibition of biomass of Nocardia nova complex biofilms. N. nova complex biofilms were grown for 24 h on silicone disks, placed in 24-well tissue culture plates, and exposed to trimethoprim/sulfamethoxazole (Bacterim) and heparin; trimethoprim, EDTA, and ethanol (EtOH); minocycline, EDTA, and ethanol; or Mueller-Hinton broth medium (control) for 2 h. Minocycline and trimethoprim-based lock solutions completely inhibited the N. nova complex biofilm biomass compared with control

Figure 2. Antibiofilm agents inhibition of biomass of Nocardia nova complex biofilms. N. nova complex biofilms were grown for 24 h on silicone disks, placed in 24-well tissue culture plates, and exposed to trimethoprim/sulfamethoxazole (Bacterim) and heparin; trimethoprim, EDTA, and ethanol (EtOH); minocycline, EDTA, and ethanol; or Mueller-Hinton broth medium (control) for 2 h. Minocycline and trimethoprim-based lock solutions completely inhibited the N. nova complex biofilm biomass compared with controls (p = 0.003).

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