Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
Aeron C. Hurt , Sook Kwan Leang, David J. Speers, Ian G. Barr, and Sebastian Maurer-Stroh
Author affiliations: World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia (A.C. Hurt, S.K. Leang, I.G. Barr); PathWest Laboratory Medicine, Nedlands, Western Australia, Australia (D.J. Speers); Agency for Science, Technology and Research, Singapore (S. Maurer-Stroh); Ministry of Health, Singapore (S. Maurer-Stroh); Nanyang Technological University, Singapore (S. Maurer-Stroh)
Figure 2. Comparison of wildtype I117 mutation from pandemic (H1N1) 2009 viruses (green residues; Protein Data Bank: 3nss) with FoldX/YASARA model of I117V + H275Y double mutant (red residues) (11,12). Residue numbering is according to pandemic (H1N1) 2009 neuraminadase. Oseltamivir is added as reference (Protein Data Bank: 3clO) and shown in magenta.
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