Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 18, Number 1—January 2012

Dispatch

Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

Aeron C. HurtComments to Author , Sook Kwan Leang, David J. Speers, Ian G. Barr, and Sebastian Maurer-Stroh
Author affiliations: World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia (A.C. Hurt, S.K. Leang, I.G. Barr); PathWest Laboratory Medicine, Nedlands, Western Australia, Australia (D.J. Speers); Agency for Science, Technology and Research, Singapore (S. Maurer-Stroh); Ministry of Health, Singapore (S. Maurer-Stroh); Nanyang Technological University, Singapore (S. Maurer-Stroh)

Main Article

Table 2

Predicted local structure destabilization for the different NA mutations from pandemic (H1N1) 2009 viruses*

NA mutation Mean ± SD level of destabilization, kcal/mol†
H275Y 4.7 ± 0.4
H275Y + I117V 5.2 ± 0.4
H275Y + I117M 5.0 ± 0.3
I117V 0.5 ± 0.02
I117M 0.1 ± 0.1

*NA, neuraminidase.
†Calculated with FoldX (11) on the basis of 5 repetitions.

Main Article

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO