Volume 18, Number 12—December 2012
Dispatch
Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease
Simon Nicot, Anna Bencsik, Eric Morignat, Nadine Mestre-Francés, Armand Perret-Liaudet, and Thierry Baron
Table
Comparison of transmission of sCJD and L-BSE in hamsters and mice
| Hosts and inoculum | Passage | Mean survival time, dpi ± SD | No. brain PrPd positive/no. tested | No. spleen PrPres positive/no. tested |
|---|---|---|---|---|
| Syrian golden hamsters | ||||
|
sCJD MM2-cortical |
1 | 833 ± 33 | 0/4 | 0/4 |
|
L-BSE lemur |
1 | 529 ± 177 | 5/5 | 1/4 |
|
L-BSE cattle (02-2528) |
1 | 622 ± 64† | 4/5† | 0/5 |
| TgOvPrP4 mice | ||||
|
sCJD MM2-cortical |
1 | 639 ± 49 | 3/4 | 0/4 |
|
L-BSE lemur |
1 | 509 ± 97 | 7/7 | 7/7 |
|
L-BSE cattle (02-2528) |
1 | 627 ± 74‡ | 9/10‡ | 0/5§ |
|
L-BSE cattle (08-0074) |
1 | 497 ± 49 | 6/8 | 0/9 |
|
sCJD MM2-cortical |
2 | 111 ± 25 | 12/12 | 12/12 |
|
L-BSE lemur |
2 | 194 ± 7 | 12/12 | 12/12 |
|
L-BSE cattle (02-2528) |
2 | 202 ± 26‡ | 9/9‡ | 3/5 |
|
L-BSE cattle (08-0074) |
2 | 186 ± 37 | 12/12 | 9/11 |
*Isolate identification numbers are shown in parentheses. sCJD, sporadic Creutzfeldt-Jakob disease; L-BSE, L-type bovine spongiform encephalopathy; TgOvPrP4, ovine prion protein–transgenic; dpi, days postinoculation; PrPd, disease-associated prion protein; PrPres, protease-resistant prion protein.
†Data from (7).
‡Data from (8).
§Data from (10).
