Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 18, Number 2—February 2012
Letter

Zika Virus Infection, Cambodia, 2010

Vireak Heang, Chadwick Y. Yasuda, Ly Sovann, Andrew D. Haddow, Amelia P Travassos da Rosa, Robert B. Tesh, and Matthew R. Kasper1Comments to Author 
Author affiliations: US Naval Medical Research Unit No. 2, Phnom Penh, Cambodia (V. Heang, C.Y. Yasuda); Ministry of Health, Phnom Penh (L. Sovann); University of Texas Medical Branch, Galveston, Texas, USA (A.D. Haddow, A.P. Travassos da Rosa, R.B. Tesh); US Naval Medical Research Unit No. 2, Jakarta, Indonesia (M.R. Kasper)

Main Article

Table

Reported or observed clinical signs and symptoms in persons with Zika virus infection, 1962–2010

Sign or symptom Country, year of infection origin,* no. (%) patients
Uganda, 1962, n = 1 Laboratory acquired, 1973, n = 1 Indonesia,
1977–1978, n = 7 Micronesia, 2007, n = 28 Senegal/United States, 2009, n = 3 Cambodia, 2010, n = 1
Fever 1 (100) 1 (100) 7 (100) 20 (65) 1 (100)
Headache 1 (100) 14 (45) 3 (100) 1 (100)
Malaise 1 (100) 5 (71) 3 (100)
Maculopapular rash 1 (100) 28 (100) 3 (100)
Fatigue or myalgia 1 (100) 1 (100) 1 (14) 14 (45) 1 (33)
Arthritis and arthralgia 1 (14) 20 (65) 3 (100)
Chills 1 (100) 2 (29) 2 (67)
Dizziness 5 (71)
Joint swelling or edema 6 (19) 2 (67)
Stomachache 6 (86)
Retro-orbital pain 1 (100) 12 (39)
Conjunctivitis 1 (14) 17 (55) 1 (33)
Anorexia 4 (57)
Photophobia 1 (33)
Vomiting 1 (14) 3 (10)
Diarrhea 3 (43)
Constipation 3 (43)
Sore throat 1 (100)
Cough 1 (100)
Aphthous ulcer 2 (67)
Hypotension 2 (29)
Hematuria 1 (14)
Prostatitis 1 (33)
Hematospermia 1 (33)
Sweating 1 (100)
Lightheadedness 1 (33)

*References: Uganda (2), laboratory-acquired (10), Indonesia (5), Micronesia (9), Senegal/United States (4). Blank cells indicate no reported information.

Main Article

References
  1. Dick  GW, Kitchen  SF, Haddow  AJ. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;46:509–20. DOIPubMedGoogle Scholar
  2. Simpson  DI. Zika virus infection in man. Trans R Soc Trop Med Hyg. 1964;58:335–8. DOIPubMedGoogle Scholar
  3. Duffy  MR, Chen  TH, Hancock  WT, Powers  AM, Kool  JL, Lanciotti  RS, Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360:2536–43. DOIPubMedGoogle Scholar
  4. Foy  BD, Kobylinski  KC, Chilson Foy  JL, Blitvich  BJ, Travassos da Rosa  A, Haddow  AD, Probable non–vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis. 2011;17:880–2.PubMedGoogle Scholar
  5. Olson  JG, Ksiazek  TG. Suhandiman, Triwibowo. Zika virus, a cause of fever in Central Java, Indonesia. Trans R Soc Trop Med Hyg. 1981;75:389–93. DOIPubMedGoogle Scholar
  6. Moureau  G, Temmam  S, Gonzalez  JP, Charrel  RN, Grard  G, de Lamballerie  X. A real-time RT-PCR method for the universal detection and identification of flaviviruses. Vector Borne Zoonotic Dis. 2007;7:467–77. DOIPubMedGoogle Scholar
  7. Santhosh  SR, Parida  MM, Dash  PK, Pateriya  A, Pattnaik  B, Pradhan  HK, Development and evaluation of SYBR Green I-based one-step real-time RT-PCR assay for detection and quantitation of Japanese encephalitis virus. J Virol Methods. 2007;143:73–80. DOIPubMedGoogle Scholar
  8. Reynes  JM, Ong  S, Mey  C, Ngan  C, Hoyer  S, Sall  AA. Improved molecular detection of dengue virus serotype 1 variants. J Clin Microbiol. 2003;41:3864–7. DOIPubMedGoogle Scholar
  9. Lanciotti  RS, Calisher  CH, Gubler  DJ, Chang  GJ, Vorndam  AV. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol. 1992;30:545–51.PubMedGoogle Scholar
  10. Filipe  AR, Martins  CM, Rocha  H. Laboratory infection with Zika virus after vaccination against yellow fever. Arch Gesamte Virusforsch. 1973;43:315–9. DOIPubMedGoogle Scholar

Main Article

1Current affiliation: US Naval Medical Research Unit No. 6, Lima, Peru.

Page created: January 24, 2012
Page updated: January 24, 2012
Page reviewed: January 24, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external