Volume 18, Number 4—April 2012
Dispatch
Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB
Jurriaan E.M. de Steenwinkel
, Marian T. ten Kate, Gerjo J. de Knegt, Kristin Kremer, Rob E. Aarnoutse, Martin J. Boeree, Henri A. Verbrugh, Dick van Soolingen, and Irma A.J.M. Bakker-Woudenberg
, Marian T. ten Kate, Gerjo J. de Knegt, Kristin Kremer, Rob E. Aarnoutse, Martin J. Boeree, Henri A. Verbrugh, Dick van Soolingen, and Irma A.J.M. Bakker-WoudenbergTable 1
Mutation frequency of Mycobacterium tuberculosis genotype strains originating from Vietnam, by antituberculosis drug
| Genotype | Frequency of mutation among strains* |
|||
|---|---|---|---|---|
| Isoniazid | Rifampin | Moxifloxacin | Amikacin | |
| Beijing | ||||
| 1585 | 5.7 × 10−6, 6.2 × 10−6 | 3.0 × 10−3, 4.3 × 10−3 | 4.3 × 10−8, 6.1 × 10−8 | 2.3 × 10−8, 3.2 × 10−8 |
| 1607 | 8.6 × 10−6, 1.4 × 10−5 | 1.5 × 10−3, 5.4 × 10−3 | 6.9 × 10−8, 2.4 × 10−7 | 8.6 × 10−8, 3.0 × 10−7 |
| 2115 | 7.3 × 10−6, 1.1 × 10−5 | 1.0 × 10−3, 9.2 × 10−5 | 1.0 × 10−8, 4.3 × 10−8 | 1.4 × 10−8, 2.8 × 10−8 |
| 2121 | 6.8 × 10−5, 2.9 × 10−4 | 2.9 × 10−5, 1.9 × 10−4 | 1.1 × 10−7, 1.6 × 10−7 | 9.3 × 10−8, 1.1 × 10−7 |
| 2145 | 9.1 × 10−4, 5.0 × 10−4 | 1.6 × 10−5, 5.5 × 10−5 | 7.9 × 10−8, 1.0 × 10−7 | 7.6 × 10−7, 1.1 × 10−6 |
| East-African/Indian | ||||
| 1627 | 3.7 × 10−6, 6.5 × 10−6 | 4.1 × 10−6, 2.8 × 10−6 | 9.3 × 10−9, 1.5 × 10−7 | 5.6 × 10−8, 4.5 × 10−9 |
| 1606 | 8.7 × 10−6, 1.6 × 10−4 | 3.8 × 10−4, 2.7 × 10−5 | 3.2 × 10−8, 1.0 × 10−7 | 7.5 × 10−9, 1.5 × 10−9 |
| 1592 | 1.8 × 10−5, 2.6 × 10−5 | 3.0 × 10−4, 2.4 × 10−5 | 9.9 × 10−8, 4.5 × 10−8 | 9.4 × 10−8, 1.5 × 10−9 |
| 1596 | 3.9 × 10−5, 2.8 × 10−5 | 1.4 × 10−5, 3.9 × 10−6 | 1.7 × 10−7, 2.0 × 10−7 | 3.7 × 10−8, 3.2 × 10−7 |
| 2113 | 1.3 × 10−5, 4.1 × 10−5 | 6.7 × 10−8, 6.3 × 10−8 | 1.5 × 10−8, 1.0 × 10−7 | 4.4 × 10−8, 3.3 × 10−7 |
*Determined in duplicate.
