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Volume 18, Number 4—April 2012

Dispatch

Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

Jurriaan E.M. de SteenwinkelComments to Author , Marian T. ten Kate, Gerjo J. de Knegt, Kristin Kremer, Rob E. Aarnoutse, Martin J. Boeree, Henri A. Verbrugh, Dick van Soolingen, and Irma A.J.M. Bakker-Woudenberg
Author affiliations: Erasmus University Medical Center, Rotterdam, the Netherlands (J.E.M. de Steenwinkel, M.T. ten Kate, G.J. de Knegt, H.A. Verbrugh, I.A.J.M. Bakker-Woudenberg); National Institute of Public Health and the Environment Center for Infectious Disease Control (RIVM),; Bilthoven, the Netherlands (K. Kremer, D. van Soolingen); World Health Organization Regional Office for Europe, Copenhagen, Denmark (K. Kremer); Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (R.E. Aarnoutse, M.J. Boeree, D. van Soolingen)

Main Article

Table 1

Mutation frequency of Mycobacterium tuberculosis genotype strains originating from Vietnam, by antituberculosis drug

Genotype Frequency of mutation among strains*
Isoniazid Rifampin Moxifloxacin Amikacin
Beijing
1585 5.7 × 10−6, 6.2 × 10−6 3.0 × 10−3, 4.3 × 10−3 4.3 × 10−8, 6.1 × 10−8 2.3 × 10−8, 3.2 × 10−8
1607 8.6 × 10−6, 1.4 × 10−5 1.5 × 10−3, 5.4 × 10−3 6.9 × 10−8, 2.4 × 10−7 8.6 × 10−8, 3.0 × 10−7
2115 7.3 × 10−6, 1.1 × 10−5 1.0 × 10−3, 9.2 × 10−5 1.0 × 10−8, 4.3 × 10−8 1.4 × 10−8, 2.8 × 10−8
2121 6.8 × 10−5, 2.9 × 10−4 2.9 × 10−5, 1.9 × 10−4 1.1 × 10−7, 1.6 × 10−7 9.3 × 10−8, 1.1 × 10−7
2145 9.1 × 10−4, 5.0 × 10−4 1.6 × 10−5, 5.5 × 10−5 7.9 × 10−8, 1.0 × 10−7 7.6 × 10−7, 1.1 × 10−6
East-African/Indian
1627 3.7 × 10−6, 6.5 × 10−6 4.1 × 10−6, 2.8 × 10−6 9.3 × 10−9, 1.5 × 10−7 5.6 × 10−8, 4.5 × 10−9
1606 8.7 × 10−6, 1.6 × 10−4 3.8 × 10−4, 2.7 × 10−5 3.2 × 10−8, 1.0 × 10−7 7.5 × 10−9, 1.5 × 10−9
1592 1.8 × 10−5, 2.6 × 10−5 3.0 × 10−4, 2.4 × 10−5 9.9 × 10−8, 4.5 × 10−8 9.4 × 10−8, 1.5 × 10−9
1596 3.9 × 10−5, 2.8 × 10−5 1.4 × 10−5, 3.9 × 10−6 1.7 × 10−7, 2.0 × 10−7 3.7 × 10−8, 3.2 × 10−7
2113 1.3 × 10−5, 4.1 × 10−5 6.7 × 10−8, 6.3 × 10−8 1.5 × 10−8, 1.0 × 10−7 4.4 × 10−8, 3.3 × 10−7

*Determined in duplicate.

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