Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 18, Number 4—April 2012

Dispatch

Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

Jurriaan E.M. de SteenwinkelComments to Author , Marian T. ten Kate, Gerjo J. de Knegt, Kristin Kremer, Rob E. Aarnoutse, Martin J. Boeree, Henri A. Verbrugh, Dick van Soolingen, and Irma A.J.M. Bakker-Woudenberg
Author affiliations: Erasmus University Medical Center, Rotterdam, the Netherlands (J.E.M. de Steenwinkel, M.T. ten Kate, G.J. de Knegt, H.A. Verbrugh, I.A.J.M. Bakker-Woudenberg); National Institute of Public Health and the Environment Center for Infectious Disease Control (RIVM),; Bilthoven, the Netherlands (K. Kremer, D. van Soolingen); World Health Organization Regional Office for Europe, Copenhagen, Denmark (K. Kremer); Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (R.E. Aarnoutse, M.J. Boeree, D. van Soolingen)

Main Article

Table 2

Concentration- and time-dependent bactericidal effect of rifampin toward Mycobacterium tuberculosis genotypes in low- and high-density cultures*

Day Lowest RIF concentration resulting in killing of M. tuberculosis, mg/L
Beijing-1585 genotype
EAI-1627 genotype
>99% killing
100% killing
>99% killing
100% killing
Low† High‡ Low† High‡ Low§ High¶ Low§ High¶
1 8 ND 256 ND 8 ND 32 ND
3 1 0.008 64 1024 0.125 0.03 8 32
6 0.001 0.008 2 64 0.001 0.06 1 2

*Cultures were exposed to RIF at 2-fold increasing concentrations for 6 days at 37°C; at indicated time-points, subcultures were performed on solid media for counting. Low, low-density culture; high, high-density culture; ND, not determined.
†Density of 5.1 × 105 CFU/mL.
‡Density of 4.4 × 106 CFU/mL.
§Density of 6.8 × 105 CFU/mL.
¶Density of 3.0 × 106 CFU/mL.

Main Article

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO