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Volume 18, Number 5—May 2012

Dispatch

Coxsackievirus A21, Enterovirus 68, and Acute Respiratory Tract Infection, China

Zichun Xiang, Richard Gonzalez, Zhong Wang, Lili Ren, Yan Xiao, Jianguo Li, Yongjun Li, Guy Vernet, Gláucia Paranhos-Baccalà, Qi Jin, and Jianwei WangComments to Author 
Author affiliations: MOH Key Laboratory of Systems Biology of Pathogens, Beijing, People’s Republic of China (Z. Xiang, L. Ren, J. Li, Q. Jin, J. Wang); Institute of Pathogen Biology, Beijing (Z. Xiang, R. Gonzalez, Z. Wang, L. Ren, Y. Xiao, J. Li, Q. Jin, J. Wang); Fondation Mérieux, Lyon, France (R. Gonzalez, Y. Li, G. Vernet, G. Paranhos-Baccalà); Peking Union Medical College Hospital, Beijing (Z. Wang)

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Table 2

Demographic and clinical characteristics of sampled population with human enterovirus infections, People’s Republic of China, August 2006–April 2010*

Characteristic No. (%) persons
Coxsackievirus A21, n = 34 Enterovirus 68, n = 13 Any human enterovirus, n = 130
Sex
M 18 (52.9) 7 (53.8) 69 (53.1)
F 16 (47.1) 6 (46.2) 61 (46.9)
Signs and symptoms
   Pharyngeal congestion 34 (100) 13 (100.0) 128 (98.5)
   Headache 27 (79.4) 10 (76.9) 104 (80.0)
   Myalgia 25 (73.5) 9 (69.2) 93 (71.5)
   Chills 25 (73.5) 7 (53.8) 89 (68.5)
   Sore throat 23 (67.6) 7 (53.8) 82 (63.1)
   Rhinorrhea 17 (50.0) 5 (38.5) 50 (38.5)
   Sneezing 14 (41.2) 3 (23.1) 44 (33.8)
   Cough 7 (20.6) 3 (23.1) 19 (14.6)
   Swelling of tonsils 6 (17.6) 1 (7.7) 16 (12.3)
   Expectoration 4 (11.8) 0 6 (4.6)
   Rigors 1 (2.9) 1 (7.7) 4 (3.1)
Preliminary clinical diagnosis
   Upper respiratory tract infection 33 (97.1) 13 (100.0) 126 (96.9)
   Tonsillitis 0 0 2 (1.5)
   Pulmonary infection 0 0 1 (0.8)
Other viruses co-detected 1 (2.9)† 1 (7.7)† 8 (6.2)‡

*Median age (range) of patients with coxsackievirus A21 infection, 22 (15–67) y; median age (range) of patients with enterovirus V68 infection, 34 (18–67) y; median age (range) of patients with any enterovirus infection, 27.5 (15–70) y. Median age of patients with coxsackievirus A21 infection was younger than that of patients with other human enterovirus infections (χ2 14.7; p<0.01).
†Influenza virus A (n = 1).
‡Influenza virus A (n = 2), parainfluenza virus 3 (n = 2), rhinovirus (n = 2), metapneumovirus (n = 1), coronavirus OC43 (n = 1).

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