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Volume 18, Number 5—May 2012

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Plasmodium vivax Malaria–associated Acute Kidney Injury, India, 2010–2011

Vivek B. KuteComments to Author , Hargovind L. Trivedi, Aruna V. Vanikar, Pankaj R. Shah, Manoj R. Gumber, Himanshu V. Patel, Jitendra G. Goswami, and Kamal V. Kanodia
Author affiliations: Institute of Kidney Diseases and Research Centre–Dr HL Trivedi Institute of Transplantation Sciences, Ahmedabad, India

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Table 2

Comparison of 25 Plasmodium vivax patients with acute kidney injury, Ahmedabad, India, 2010–2011*

Characteristic Survived, n = 22 Died, n = 3 p value
Age, y 27.7 ± 9.9 47.3 ± 17.5 0.058
Hypotension not resolving after receipt of fluid, no. (%) 0 3 (100) 0.0001
Mechanical ventilation, no. (%) 1 (4.5) 3 (100) 0.0001
Lactate dehydrogenase, U/L 1126.3 ± 243.2 2300 ± 360.5 0.001
APACHE 2 score 16.4 ± 2.61 (9–23) 25.3 ± 1.52 (24–27) 0.001
SOFA score 7.73 ± 2.3 (4–11) 13.3 ± 1.15 (12–14) 0.001
MODS score 7.23 ± 2.26 (4–10) 13 ± 1.0 (12–14) 0.001
GCS score 14.5 ± 1.01 (12–15) 12.3 ± 0.57 (12–13) 0.013
Hemoglobin, gm/L 8.0 ± 1.71 8.13 ± 0.70 0.96
Hematocrit, % 24.5 ± 5.2 25.6 ± 2.3 0.78
Leuckocytes, cells/mm3 9,175.9 ± 3,110 7,733.3 ± 3,300 0.49
Platelets, cells/μL 113,409 ± 96,618 74,000 ± 2,5159 0.90
Total bilirubin, mg/dL 6.1 ± 8 2.56 ± 0.75 0.72
Direct bilirubin, mg/dL 4.46 ± 6.58 1.76 ± 0.40 0.60
Indirect bilirubin, mg/dL 1.64 ± 2.23 0.80 ± 0.34 0.90
Alanine aminotransferase, U/L 66.9 ± 47.8 59.3 ± 29.1 0.96
Sodium, mmol/L 130.5 ± 7.17 126.6 ± 2.3 0.23
Creatinine, mg/dL 7.36 ± 2.7 7.5 ± 2.17 0.66
Blood urea, mg/dL 147.7 ± 57.5 87 ± 48.8 0.08
No. hemodialysis sessions 5.3 ± 3.7 3.33 ± 1.15 0.23

*Values are mean ± SD (range) except as indicated. APACHE, Acute Physiology and Chronic Health Evaluation; SOFA ,Sequential Organ Failure Assessment; MODS, Multiple Organ Dysfunction Score; GCS, Glasgow Coma Scale.

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