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Volume 18, Number 6—June 2012

Letter

Pneumococcal Serotype–specific Unresponsiveness in Vaccinated Child with Cochlear Implant

Elaine Stanford, Shamez LadhaniComments to Author , Mary Slack, David Scott, Alec Fitzgerald-O’Connor, Pauline Waight, Rashmi Malkani, and Ray Borrow
Author affiliations: Health Protection Agency, Manchester, UK (E. Stanford, R. Borrow); Health Protection Agency, London, UK (S. Ladhani, M. Slack, P. Waight, R. Malkani); East Sussex Hospitals National Health Service Trust, Conquest Hospital, St Leonards-on-Sea, UK (D. Scott); St Thomas’ Hospital London, London (A. Fitzgerald-O’Connor); University of Manchester, Manchester (R. Borrow)

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Table

. Pneumococcal serotype-specific IgG concentrations in 2-year-old child with recurrent pneumococcal meningitis, United Kingdom*

Patient age, mo Event Serotype-specific IgG, µg/mL
4 6B 9V 14 18C 19F 23F
1.9 PCV7 dose 1
3.9 PCV7 dose 2
13.4 PCV7 dose 3
22.8 Cochlear implant
23.4 Pneumococcal meningitis (episode 1)
24.4 PCV7 dose 4
25.6 Pneumococcal serologic testing 0.12 27.6 23.0 36.9 13.8 57.0 41.1
27.8 PPV23 dose 1
28.8 Pneumococcal serologic testing 0.18 14.2 13.1 30.4 11.4 11.7 32.0
32.0 Pneumococcal meningitis (episode 2)
35.1 PCV7 dose 5
36.1 Pneumococcal serologic testing 0.20 18.40 7.12 12.50 12.40 2.78 37.1
39.0 PCR positive nasopharyngeal swab specimen for Streptococcus pneumoniae serotype 4

*PCV7, 7-valent pneumococcal conjugate vaccine; PPV23, 23-valent pneumococcal polysaccharide vaccine. Blank spaces indicate not tested.

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