Volume 18, Number 6—June 2012
Research
Intrafamilial Circulation of Tropheryma whipplei, France
Florence Fenollar, Alpha K. Keita, Sylvain Buffet, and Didier Raoult
Table 2
Tropheryma whipplei genotyping for patients and their family members, France, 2003–2011*
| Study participant | PCR result | HVGS1 | HVGS2 | HVGS3 | HVGS4 | Genotype | Lived in household of index patient |
|---|---|---|---|---|---|---|---|
| Patient 1 family | |||||||
| Patient 1 | + | 1 | 1 | 1 | 3 | 1 | Index patient |
| Father | + | 1 | 1 | 1 | 3 | 1 | No |
| Mother | + | 1 | 1 | 1 | 3 | 1 | No |
| Patient 10 family | |||||||
| Patient 10 | + | 8 | 1 | 2 | 3 | 19 | Index patient |
| Husband | + | 8 | 1 | 2 | 3 | 19 | Yes |
| Son | – | NA | NA | NA | NA | NA | Yes |
| Daughter | – | NA | NA | NA | NA | NA | Yes |
| Patient 11 family | |||||||
| Patient 11 | + | 1 | 6 | 1 | 1 | 3 | Index patient |
| Husband | + | 1 | 6 | 1 | 1 | 3 | Yes |
| Patient 7 family | |||||||
| Patient 7 | + | 1 | 1 | 1 | 3 | 1 | Index patient |
| Son | + | 1 | 6 | 1 | 1 | 3 | No |
| Daughter | + | NA | NA | NA | NA | NA | No |
| Wife | – | NA | NA | NA | NA | NA | Yes |
| Carrier 3 family | |||||||
| Carrier 3 | + | 1 | 1 | 25 | 3 | 82 | Index patient |
| Sister | + | 1 | 6 | 5 | 1 | 83 | No |
| Mother | + | 1 | 6 | 5 | 1 | 83 | No |
| Niece 1 | + | 1 | 6 | 1 | 1 | 3 | No |
| Niece 2 | + | 1 | 6 | 1 | 1 | 3 | No |
| Father | – | NA | NA | NA | NA | NA | No |
| Nephew 3 | – | NA | NA | NA | NA | NA | No |
*HVGS, highly variable genomic sequences; +, positive; –, negative; NA, not available.
