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Volume 18, Number 7—July 2012


Spike Protein Fusion Peptide and Feline Coronavirus Virulence

Hui-Wen Chang, Herman F. Egberink, Rebecca Halpin, David J. Spiro, and Peter J.M. RottierComments to Author 
Author affiliations: Utrecht University, Utrecht, the Netherlands (H.-W. Chang, H.F. Egberink, P.J.M. Rottier); and J. Craig Venter Institute, Rockville, Maryland, USA (R. Halpin, D.J. Spiro)

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Table 2

Prevalence of alternative mutations in feline infectious peritonitis virus spike protein of cats with wet and dry forms of FIP*

Mutation Pathologic form of FIP
Wet Dry
M1058L 71 46
S1060A 5 1
No mutation 3 3
Total 79 50

*Cats were diagnosed with the dry or wet form of FIP (feline infectious peritonitis) during postmortem examination by a veterinary pathologist. The occurrence and nature of the mutation in the spike gene was established by sequencing.

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