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Volume 18, Number 8—August 2012

Dispatch

Severe Human Granulocytic Anaplasmosis Transmitted by Blood Transfusion

Matjaz JerebComments to Author , Blaz Pecaver, Janez Tomazic, Igor Muzlovic, Tatjana Avsic-Zupanc, Tanja Premru-Srsen, Snezna Levicnik-Stezinar, Primoz Karner, and Franc Strle
Author affiliations: University Medical Center Ljubljana, Ljubljana, Slovenia (M. Jereb, B. Pecaver, J. Tomazic, I. Muzlovic, T. Premru-Srsen); Institute of Microbiology and Immunology, Ljubljana (T. Avsic-Zupanc); and Blood Transfusion Center of Slovenia, Ljubljana (S. Levicnik-Stezinar)

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Table 2

Results of PCR and IFA for IgG against Anaplasma. phagocytophilum for index patient and blood donor, Slovenia, 2010*

Date, 2010 Patient
Donor
PCR IFA Remarks PCR IFA Remarks
May 12† 118 d before index donation
Aug 28–29 ND ND Febrile illness
Sep

7†

+ >1,024 Index donation

15

Transfusion

25

ND ND Onset of febrile illness
Oct

1

+‡ Treatment with doxycycline Oct 1–14

4

+ 128

6

+ 512

9

+ ND

10

ND

12

512

19

ND 512

20

>1,024 43 d after index donation
Nov 23 ND >1,024 No reports of problems

*Results for IFA are shown in titers. IFA, immunofluorescence assay; ND, not done; –, negative; +, positive.
†Retrospective testing of stored blood specimen.
‡DNA detected in stored bone marrow–biopsy specimen.

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