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Volume 18, Number 8—August 2012

Research

Solid Organ Transplant–associated Lymphocytic Choriomeningitis, United States, 2011

Adam MacNeilComments to Author , Ute Ströher, Eileen Farnon, Shelley Campbell, Deborah Cannon, Christopher D. Paddock, Clifton P. Drew, Matthew Kuehnert, Barbara Knust, Robert Gruenenfelder, Sherif R. Zaki, Pierre E. Rollin, Stuart T. Nichol, and the LCMV Transplant Investigation Team
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A. MacNeil, U. Ströher, E. Farnon, S. Campbell, D. Cannon, C.D. Paddock, C.P. Drew, M. Kuehnert, B. Knust, S.R. Zaki, P.E. Rollin, S.T. Nichol); and Arkansas Organ Recovery Agency, Little Rock, Arkansas, USA (R. Gruenenfelder)

Main Article

Table 2

Summary of laboratory test results for an organ donor and 4 transplant recipients, United States, 2011*

Patient Time of sample collection Specimen type RT-PCR result Serology IHC
Organ donor Postmortem Serum Neg IgM neg, IgG neg NA
Postmortem Autopsy tissues Pos† NA Neg‡
Postmortem Cornea Neg NA Neg
Left kidney recipient 11 d before transplant Serum Neg IgM neg, IgG neg NA
22 d after transplant Bronchoalveolar lavage Pos IgM neg, IgG neg NA
Right kidney recipient 14 d before transplant Serum Neg IgM neg, IgG neg NA
11 d after transplant Bone marrow Neg§ NA Neg§
32 d after transplant CSF Pos IgM neg, IgG neg NA
Liver recipient 7 d before transplant Serum ND IgM neg, IgG neg NA
Before transplant Liver Neg NA Neg
9 d after transplant Liver Pos NA Pos
24 d after transplant Serum Pos¶ IgM pos (1,600), IgG neg NA
25 d after transplant Liver Pos NA Pos
37 d after transplant Liver Pos NA Pos
51 d after transplant Serum Neg IgM pos (>6,400), IgG neg NA
98 d after transplant Serum Neg IgM pos (>6,400), IgG neg NA
Lung recipient 20 d after transplant Autopsy tissues Pos# NA Pos**
Cornea recipient 4 mo after transplant Serum ND IgM neg, IgG neg NA

*RT-PCR, reverse transcription PCR; IHC, immunohistochemical testing; neg, negative; NA, not applicable; pos, positive; CSF, cerebrospinal fluid; ND, not done.
†Lymph node positive; spleen negative.
‡Central nervous system, spinal cord, trachea, lung, gastrointestinal tract, spleen, and mesenteric lymph node negative.
§Bone marrow aspirate and biopsy specimens negative.
¶Virus was isolated from this specimen.
#Lung and liver positive.
**Bladder, pancreas, right lung, left lung, stomach, spleen, gall bladder, right adrenal gland, kidney, and liver positive; left ventricle negative.

Main Article

1Additional members of the LCMV Transplant Investigation Team who contributed data are listed at the end of the article.

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