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Volume 18, Number 9—September 2012

Dispatch

Rapid Detection of Carbapenemase-producing Enterobacteriaceae

Patrice NordmannComments to Author , Laurent Poirel, and Laurent Dortet
Author affiliations: Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France (P. Nordmann, L. Poirel, L. Dortet); and Institut National de la Santé et de la Recherche Médicale, Paris, France (P. Nordmann, L. Poirel, L. Dortet)

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Table 2

Non–carbapenemase-producing clinical enterobacterial isolates subjected to the Carba NP test*

β-Lactamase type, species β-Lactamase No. MIC, mg/L
Carba NP test result
IMP ERT MER
ESBLs
Klebsiella pneumoniae CTX-M-3 1 0.12 0.12 0.12
CTX-M-14 1 0.12 0.12 0.12
CTX-M-15 3 0.12 0.12 0.12
Escherichia coli CTX-M-1 1 0.12 0.12 0.12
CTX-M-3 1 0.12 0.12 0.12
CTX-M-14 2 0.12 0.12 0.12
CTX-M-15 2 0.12 0.12 0.12
VEB-1 1 0.12–0.25 0.12 0.12
Enterobacter cloacae CTX-M-15 3 0.12 0.12 0.12

VEB-1
1
0.12
0.12
0.12

Plasmid-mediated AmpC or chromosomal AmpC + decreased membrane permeability
K. pneumoniae DHA-1 1 >32 >32 >32
DHA-2 1 0.12 0.5 0.12
E. coli Extended-spectrum cephalosporinase 1 0.12 0.12 0.12
CMY-2 1 0.12 0.12 0.12
CMY-10 1 0.12 0.38 0.12
DHA-1 1 0.12 0.12 0.12
ACC-1 1 0.12 0.12 0.12
Overexpressed cephalosporinase 1 16 >32 2
Proteus mirabilis ACC-1 1 0.25 0.12 0.12
E. cloacae Overexpressed cephalosporinase 7 0.12–16 1–>32 0.12–>32
Enterobacter aerogenes Overexpressed cephalosporinase 1 1 4 0.75
Morganella morganii
Overexpressed cephalosporinase
2
1.5–2
0.12
0.5

ESBL + decreased membrane permeability
K. pneumoniae CTX-M-15 8 0.25–8 1–>32 1–>32
SHV-28 1 1 4 1
SHV-2a 1 0.25 2 0.38
Enterobacter sakazakii CTX-M-15 1 0.25 1.5 0.25
Citrobacter freundii TEM-3 1 1 8 1

*IMP, imipenem; ERT, ertapenem; MER, meropenem; ESBLs, extended-spectrum β-lactamases.

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