Figure. . . IPD clinical cases in PCV7-eligible children since PCV7 introduction, England and Wales, September 4, 2006–March 31, 2010. A) Distribution of cases. Black bar sections, bacteremia; dark gray bar sections, lower respiratory tract infection; light gray bar sections, meningitis; white bar sections, other. B) Proportion of serotyped cases caused by PCV7 serotypes in healthy children (dashed line) and children with comorbidities (solid line). The prevalences of comorbidity among IPD cases during the 4 time periods were 13,5%, 17.7%, 17.0%, and 10.7%, and the case-fatality rates were 5.6%, 4.3%, 4.3%, and 3.0%, respectively. *Data included for 7 months only. IPD, invasive pneumococcal disease; PCV7, 7-valent pneumococcal conjugate vaccine.