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Volume 19, Number 2—February 2013


Human Granulocytic Anaplasmosis, Japan

Norio Ohashi1Comments to Author , Gaowa1, Wuritu, Fumihiko Kawamori, Dongxing Wu, Yuko Yoshikawa, Seizou Chiya, Kazutoshi Fukunaga, Toyohiko Funato, Masaaki Shiojiri2, Hideki Nakajima3, Yoshiji Hamauzu, Ai Takano, Hiroki Kawabata, Shuji Ando, and Toshio Kishimoto

Author affiliations: University of Shizuoka and Global Center of Excellence Program, Shizuoka City, Japan (N. Ohashi, Gaowa, Wuritu, F. Kawamori, D. Wu, Y. Yoshikawa); Kochi Institute of Health, Kochi City, Japan (S. Chiya, K. Fukunaga); Shizuoka Institute of Environment and Hygiene, Shizuoka City (F. Kawamori); Muroto Hospital, Muroto, Japan (T. Funato); Kochi Prefectural Aki Hospital, Aki City, Japan (M. Shiojiri, H. Nakajima); Chu-gei Clinic, Aki District, Japan (Y. Hamauzu); National Institute of Infectious Diseases, Tokyo, Japan (A. Takano, H. Kawabata, S. Ando); Okayama Prefectural Institute for Environmental Science and Public Health, Okayama, Japan (T. Kishimoto)

Main Article

Table 2

Detection of IgM and IgG in serum samples from 2 men with human granulocytic anaplasmosis, Kochi Prefecture, Japan*

Days after symptom onset Antibody titers, IgM/IgG†
R. japonica, cultured in L929 cells‡ O. tsutsugamushi, cultured in L929 cells§ Anaplasma phagocytophilum, propagated in
HL60 cells THP-1 cells
Case-patient 1
3 <20/<20 <20/<20 <20/<20 80/<20
Case-patient 2
4 <20/<20 <20/<20 20/<20 40/40
11 <20/320 <20/<20 <20/<20 160/80

*All Western blot testing using recombinant P44-1 antigen detected IgM and IgG; the antigen reacted with all sera tested, as shown in Figure 2.
†Determined by using indirect immunofluorescence assay.
Rickettsia japonica strain YH.
§Orientia tsutsugamushi strains Gilliam, Karp, Kato, and Kawasaki.

Main Article

1These authors contributed equally to this article.

2Current affiliation: Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan.

3Current affiliation: Kochi Medical School, Nankoku, Kochi, Japan.

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