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Volume 19, Number 8—August 2013

Research

Extended-Spectrum β-Lactamase– and AmpC-Producing Enterobacteria in Healthy Broiler Chickens, Germany

Felix Reich, Viktoria Atanassova, and Günter KleinComments to Author 
Author affiliations: University of Veterinary Medicine Hannover, Hannover, Germany

Main Article

Table 2

MIC50 and MIC90distribution in Escherichia coli of ESBL or AmpC producers in broiler chickens, Germany, 2010*

FEP FEP/CLA CTX CTX/CLA FOX CPD CPD/CLA CAZ CAZ/CLA ATM TZP CIP NAL CHL TET TMP/SXT MEM GEN STR
Breakpoint, µg/mL >8 >4 >4 >32† >2 >8 >8 >32 >2 >32 >16 >16† >8 >16 >8
ECOFF
<0.125

<0.25
<0.25
<8
<2

<0.5

<0.25
<8
<0.064
<16
<16
<8
<1
<0.125
<2
<16
Total, n = 76
MIC50 2 <0.25 16 1 8 >32 1 16 0.5 2 2 <0.06 8 8 16 0.25 <0.063 0.5 32
MIC90
32
1
>32
16
>64
>32
>32
>32
32
8
4
1
>128
64
>16
>8
<0.063
1
>64
ESBL, n = 42
MIC50 8 <0.25 32 <0.25 4 >32 <0.25 8 <0.25 2 <1 0.125 16 8 >16 0.25 <0.063 0.5 32
MIC90
>32
<0.25
>32
1
8
>32
1
32
0.5
4
2
2
>128
64
>16
>8
<0.063
1
>64
ESBL, AmpC, n = 13
MIC50 2 <0.25 16 16 64 >32 >32 32 16 4 4 0.25 128 32 >16 0.125 <0.063 0.5 >64
MIC90
8
0.5
32
32
>64
>32
>32
>32
32
8
4
0.5
128
64
>16
>8
<0.063
1
>64
AmpC, n = 21
MIC50 0.5 0.5 16 16 64 >32 >32 32 16 2 4 <0.063 2 4 1 <0.063 <0.063 0.5 4
MIC90 1 1 32 16 >64 >32 >32 32 32 >8 8 0.25 128 16 16 0.25 <0.063 1 >64

*ESBL, extended spectrum β-lactamase; FEP, cefepime; FEP/CLA, cefepime/clavulanic acid; CTX, cefotaxime; CTX/CLA, cefotaxime/clavulanic acid; FOX, cefoxitin; CPD, cefpodoxime; CPD/CLA, cefpodoxime/clavulanic acid; CAZ, ceftazidime; CAZ/CLA, ceftazidime/clavulanic acid; ATM, aztreonam; TZP, piperacilin/tazobactam; CIP, ciprofloxacin; NAL, nalidixic acid; CHL, chloramphenicol; TET, tetracycline; TMP/SXT, trimethoprim/sulfamethoxazole; MEM, meropenem; GEN, gentamicin; STR, streptomycin; ECOFF, epidemiologic cutoff value.

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