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Volume 20, Number 3—March 2014

Research

Hendra Virus Vaccine, a One Health Approach to Protecting Horse, Human, and Environmental Health

Deborah Middleton1Comments to Author , Jackie Pallister1, Reuben Klein, Yan-Ru Feng, Jessica Haining, Rachel Arkinstall, Leah Frazer, Jin-An Huang, Nigel Edwards, Mark Wareing, Martin Elhay, Zia Hashmi, John Bingham, Manabu Yamada, Dayna Johnson, John White, Adam Foord, Hans G. Heine, Glenn A. Marsh, Christopher C. Broder, and Lin-Fa Wang
Author affiliations: CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia (D. Middleton, J. Pallister, R. Klein, J. Haining, R. Arkinstall, L. Frazer, J. Bingham, D. Johnson, J. White, A. Foord, H.G. Heine, G.A. Marsh, L.-F. Wang); Uniformed Services University, Bethesda, Maryland, USA (Y.-R. Feng, C.C. Broder); Zoetis Research & Manufacturing Pty Ltd, Parkville, Victoria, Australia (J.-A. Huang, N. Edwards, M. Wareing, M. Elhay, Z. Hashmi); National Institute of Animal Health, Ibaraki, Japan (M. Yamada); Duke–NUS (Duke and the National University of Singapore) Graduate Medical School, Singapore (L.-F. Wang)

Main Article

Table 1

Details, by efficacy trial number, of subunit vaccine formulations containing recombinant Hendra virus soluble G glycoprotein*

Trial no., horse identification Hendra virus soluble G glycoprotein specification
Challenge, days after vaccination Viral infectivity control
Source Irradiation Dose, μg Species No.
1 Horse 1
V1 293F HEK No 100 21
V2
293F HEK
No
100

21



2 Guinea pig 4
V3 293F HEK No 50 21
V4 293F HEK No 50 21
V5
293F HEK
No
50

21



3 Ferret 2
V6 CHO Yes 100 21
V7
CHO
Yes
100

21



4 Ferret 2
V8 CHO Yes 100 194
V9 CHO Yes 100 194
V10 CHO Yes 100 194

*HEK, human embryonic kidney cells; CHO, Chinese hamster ovary cells.

Main Article

1These authors contributed equally to this article.

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