Volume 20, Number 9—September 2014
CME ACTIVITY - Research
Pneumocystis jirovecii Pneumonia in Patients with or without AIDS, France
Table 1
Characteristic | AIDS patients, n = 223 | Non-AIDS patients, n = 321 | p value |
---|---|---|---|
Clinical features | |||
Prophylaxis prescribed† | 3 (1) | 12 (4) | 0.06 |
Temperature >38°C | 165 (74) | 263 (82) | 0.05 |
Days from constitutional symptom onset to diagnosis, median (IQR) | 30 (14–60) | 7 (2–15) | <0.0001 |
Shock |
5 (2.2) |
23 (7) |
0.01 |
Respiratory symptoms | |||
Cough | 170 (76.2) | 173 (54) | <0.0001 |
Dyspnea | 176 (79) | 234 (73) | 0.10 |
Days from respiratory symptom onset to diagnosis, median (IQR) |
21 (7–30) |
5 (1–15) |
<0.0001 |
Laboratory test results | |||
SpO2, median (IQR) | 95 (90–97) | 91 (86–96) | 0.003 |
Lymphocyte count, cells/mm3, median (IQR) | 802 (499–1,200) | 500 (278–880) | 0.0004 |
CD4+ T-cell count, cells/mm3, median (IQR) | 167 (89–342) | 32 (12–75) | <0.0001 |
C-reactive protein |
48 (17–128) |
120 (59–210) |
<0.0001 |
Radiologic findings | |||
Chest radiograph results typical for PCP | 183 (82) | 247 (77) | 0.23 |
Chest radiograph results atypical for PCP‡ | 31 (14) | 48 (15) | 0.66 |
Pneumothorax | 7 (3.1) | 7 (2.2) | 0.50 |
Chest radiograph results unremarkable | 9 (4) | 26 (8) | 0.34 |
Atypical computed tomography scan pattern§ | 15 (14) | 22 (14) | 0.47 |
*Values are no. (%) patients except as indicated. Data were missing for CD4+ T-cell count (372 patients), C-reactive protein (274 patients), and CT scan pattern (265 patients). PCP, Pneumocystis jirovecii pneumonia; IQR, interquartile range.
†Adherence to prescribed prophylaxis was unknown. Among already known HIV+ patients without prophylaxis and with available CD4+ T cell count (n = 74), median CD4+ T cell count was 33 cells/mm3 (range 12–85).
‡Defined as focal interstitial or alveolar consolidation.
§Defined as subpleural nodules, focal condensation, cavitation, or marked pleural effusion.
1Deceased.
Page created: August 14, 2014
Page updated: August 14, 2014
Page reviewed: August 14, 2014
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