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Volume 22, Number 11—November 2016
Research

Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015

Wenfei Zhu1, Hong Zhang1, Xingyu Xiang1, Lili Zhong, Lei Yang, Junfeng Guo, Yiran Xie, Fangcai Li, Zhihong Deng, Hong Feng, Yiwei Huang, Shixiong Hu, Xin Xu, Xiaohui Zou, Xiaodan Li, Tian Bai, Yongkun Chen, Zi Li, Junhua LiComments to Author , and Yuelong ShuComments to Author 
Author affiliations: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China (W. Zhu, L. Yang, J. Guo, Y. Xie, X. Zou, X. Li, T. Bai, Y. Chen, Z. Li, Y. Shu); Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing (W. Zhu, L. Yang, J. Guo, Y. Xie, X. Zou, X. Li, T. Bai, Y. Chen, Z. Li, Y. Shu); Hunan Provincial Center for Disease Control and Prevention, Changsha, China (H. Zhang, X. Xiang, F. Li, Z. Deng, Y. Huang, S. Hu, J. Li); Hunan Provincial People’s Hospital, Changsha (L. Zhong); Liuyang Center for Disease Control and Prevention, Liuyang, China (H. Feng, X. Xu)

Main Article

Figure 3

Illness (A) and death (B) among C57BL/6 mice inoculated with Eurasian avian-like influenza A/Jiangsu/1/2011 (JS/1/11 EA-H1N1) virus or Eurasian avian-like influenza A/Hunan/42443/2015 (HuN EA-H1N1) virus. Eight-to-ten week old female C57BL/6J mice (5/group) were inoculated intranasally with various 50% tissue culture infectious doses (TCID50) of JS/1/11 EA-H1N1 virus or HuN EA-H1N1 virus (in 50-μL of PBS) or with 50 μL mL of PBS (control group). A) Illness was assessed by weight changes over 14

Figure 3. Illness (A) and death (B) among C57BL/6 mice inoculated with Eurasian avian-like influenza A/Jiangsu/1/2011 (JS/1/11 EA-H1N1) virus or Eurasian avian-like influenza A/Hunan/42443/2015 (HuN EA-H1N1) virus. Eight-to-ten week old female C57BL/6J mice (5/group) were inoculated intranasally with various 50% tissue culture infectious doses (TCID50) of JS/1/11 EA-H1N1 virus or HuN EA-H1N1 virus (in 50-μL of PBS) or with 50 μL mL of PBS (control group). A) Illness was assessed by weight changes over 14 days and is graphed as a percentage of the average weights on the day of inoculation (day 0). Average bodyweight changes ± SD are shown. Dotted horizontal line indicates a bodyweight loss of 75%. B) Death was investigated by using a survival curve. On postinoculation day 14, mice with a bodyweight loss of >25% and those who died naturally (i.e., not including those that were euthanized) were recorded as fatalities. PBS, phosphate-buffered saline.

Main Article

1These authors contributed equally to this article.

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Page updated: October 18, 2016
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