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Volume 22, Number 12—December 2016
Research

Vertebrate Host Susceptibility to Heartland Virus

Angela M. Bosco-Lauth, Amanda E. Calvert, J. Jeffrey Root, Tom Gidlewski, Brian H. Bird, Richard A. Bowen, Atis Muehlenbachs, Sherif Zaki, and Aaron C. BraultComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (A.M. Bosco-Lauth, A.E. Calvert, A.C. Brault); Colorado State University; Fort Collins (A.M. Bosco-Lauth, R.A. Bowen); US Department of Agriculture, Fort Collins (J.J. Root, T. Gidlewski); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (B.H. Bird, A. Muehlenbachs, S.R. Zaki)

Main Article

Table 2

Viremia and antibody responses of animals experimentally inoculated with Heartland virus*

Animal Inoculum dose, PFU Mean peak titer† dpi Mean ELISA titer‡ ELISA positive, no. (%) Mean PRNT70 titer‡ PRNT70 positive, no. (%)
Mouse (C57BL/6) 104 <1.5 42§ 4.4 (0.6) 15 (94) 0.7 (0.6) 10 (63)
Chicken 104 <1.5 14 NT NA ND 0
Chicken 104 NA 42§ 3.0 (0.2) 3 (100) ND 0
Hamster 104 <1.5 42§ 4.3 (0.5) 4 (100) 1.3 (0.4) 5 (100)
Goat 105 <1.5 28 NT NA 1.0 2 (100)
Goat 105 NA 42§ 3.0 2 (100) 1.3 2 (100)
Rabbit 104 <1.5 14 NT NA ND 0
Rabbit
104
NA
42§
4.1
3 (100)
1.2 (0.2)
3 (100)
Raccoon 104 <1.5 42 NT NA 0.4 (0.6) 2 (33)

*Bold indicates initial (not given a booster immunization) sampling of a pair of animals that were later given a booster immunization. dpi, day postinoculation; NA, not assessed; ND, not detected (no titer <1:10 for any animal); NT, not tested; PRNT70, 70% plaque reduction neutralization test.
†Detection limit was 1.5 log10 PFU/mL.
‡log10 reciprocal titer (SD).
§Animals were given booster inoculations with 104 PFU of Heartland virus at 28 dpi.

Main Article

Page created: November 17, 2016
Page updated: November 17, 2016
Page reviewed: November 17, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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