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Volume 22, Number 12—December 2016
Research

Vertebrate Host Susceptibility to Heartland Virus

Angela M. Bosco-Lauth, Amanda E. Calvert, J. Jeffrey Root, Tom Gidlewski, Brian H. Bird, Richard A. Bowen, Atis Muehlenbachs, Sherif Zaki, and Aaron C. BraultComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (A.M. Bosco-Lauth, A.E. Calvert, A.C. Brault); Colorado State University; Fort Collins (A.M. Bosco-Lauth, R.A. Bowen); US Department of Agriculture, Fort Collins (J.J. Root, T. Gidlewski); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (B.H. Bird, A. Muehlenbachs, S.R. Zaki)

Main Article

Table 3

Viremia and antibody responses of interferon-α/β/γ receptor–deficient mice experimentally inoculated with Heartland virus*

Inoculum dose, PFU dpi Mean peak titer† Mean ELISA titer ELISA positive, no. (%) Mean PRNT70 titer‡ PRNT70 positive, no. (%)
104 NA 8 (1.0) NA − NA −
104 NA − NA − NA −
103 21 6.6 (1.2) 4.1 (2.0) 1 (50) NT −
102 28 5.3 (2.3) 3.9 (1.7) 1 (50) NT NT
102 32 − NT − 2.2 (0.4) 2(100)§
101 28 4.6 (2.1) 3.5 (1.4) 1 (33) 1.5 (0.6) ND
101 42 − NT − 1.3 (0.5) 1 (33)
100 28 3.4 (2.2) 2.7 (1.4) 1 (9) 1 1 (9)
100 42 − NT − 1.5 (0.6) 2 (33)

*Bold indicates initial (not given a booster immunization) sampling of a pair of animals that were later given a booster immunization. dpi, day postinoculation; NA, not applicable because uniform deaths were observed; ND, not detected; NT, not tested; PRNT70, 70% plaque reduction neutralization test; −, not assessed for titer.
†Peak titers (log10 PFU/mL of serum) (SD). Detection limit was 1.5 log10 PFU/mL.
‡log10 reciprocal titer (SD).
§Tested at 4 d postchallenge.

Main Article

Page created: November 17, 2016
Page updated: November 17, 2016
Page reviewed: November 17, 2016
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