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Volume 22, Number 4—April 2016
Research

Molecular Typing and Epidemiology of Human Listeriosis Cases, Denmark, 2002–20121

Anne Kvistholm JensenComments to Author , Jonas T. Björkman, Steen Ethelberg, Kristoffer Kiil, Michael Kemp, and Eva Møller Nielsen
Author affiliations: Statens Serum Institut, Copenhagen, Denmark (A.K. Jensen, J.T. Björkman, S. Ethelberg, K. Kiil, E.M. Nielsen); University of Southern Denmark, Odense, Denmark (A.K. Jensen, M. Kemp); Odense University Hospital, Odense (M. Kemp)

Main Article

Table 2

Clinical and subtype data associated with the most common PFGE pulsotypes of Listeria monocytogenes isolates from persons with listeriosis, Denmark, 2002–2012*

Pulsotype ST/CC Genetic lineage (PCR serogroup) No. cases Median patient age, y (range)† Infection type, no. (%)
CFR, %†
BSI CNS Pregnancy-associated Other‡
40–42 8/8 II (IIa) 82 71 (8–91) 68 (83) 11 (13) 0 (0) 3 (4) 30
38–48 8/8§ II (IIa) 40 69 (24–91) 31 (78) 7 (18) 0 (0) 2 (5) 25
3–23 2/2 I (IVb) 40 69 (1–90) 23 (58) 11 (28) 6 (15) 0 (0) 29
43–63 155/155 II (IIa) 17 75 (42–95) 15 (88) 1 (6) 0 (0) 1 (6) 41
27–20 6/6 I (IVb) 14 74 (57–98) 11 (79) 3 (21) 0 (0) 0 (0) 29
25–1 1/1 I (IVb) 13 67 (2–83) 6 (46) 6 (46) 0 (0) 1 (8) 23
41–43 9/9 II (IIc) 11 72 (53–93) 9 (82) 1 (9) 0 (0) 1 (9) 45
22–2 1/1 I (IVb) 11 72 (37–90) 5 (46) 4 (36) 2 (18) 0 (0) 11
44–61 155/155 II (IIa) 10 76 (49–91) 7 (70) 2 (20) 1 (10) 0 (0) 33
71–43¶ 9/9 II (IIa) 8 77 (44–94) 7 (88) 1 (13) 0 (0) 0 (0) 25
67–92 1/1 I (IVb) 8 74 (63–98) 7 (88) 1 (13) 0 (0) 0 (0) 25
27–18 6/6 I (IVb) 8 52 (50–76) 3 (38) 4 (50) 1 (13) 0 (0) 29
12–38 7/7 II (IIa) 8 73 (51–90) 3 (38) 5 (63) 0 (0) 0 (0) 13
35–26 59/59 I (IIb) 8 70 (55–80) 4 (50) 2 (25) 2 (25) 0 (0) 17

*Data are for pulsotypes found in >8 cases. Pulsotype is for combined AscI and ApaI pattern. BSI, blood stream infection; CC, clonal complex; CFR, case-fatality rate; CNS, central nervous system; PFGE, pulsed-field gel electrophoresis; ST, sequence type.
†Calculated for non–pregnancy-associated cases only.
‡Includes peritonitis, pleuritis, arthritis, abscesses, and osteitis.
§One of the 5 representative isolates selected for multilocus sequence typing for this pulsotype was ST120/CC8.
¶Confirmed outbreak described previously (15).

Main Article

1Preliminary results from this study were presented at the 18th International Symposium on Problems of Listeriosis (ISOPOL XVIII), September 19–22, 2013, Goa, India.

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