Volume 22, Number 4—April 2016
Research
Molecular Typing and Epidemiology of Human Listeriosis Cases, Denmark, 2002–20121
, Jonas T. Björkman, Steen Ethelberg, Kristoffer Kiil, Michael Kemp, and Eva Møller Nielsen
Table 2
Clinical and subtype data associated with the most common PFGE pulsotypes of Listeria monocytogenes isolates from persons with listeriosis, Denmark, 2002–2012*
| Pulsotype | ST/CC | Genetic lineage (PCR serogroup) | No. cases | Median patient age, y (range)† | Infection type, no. (%) |
CFR, %† | |||
|---|---|---|---|---|---|---|---|---|---|
| BSI | CNS | Pregnancy-associated | Other‡ | ||||||
| 40–42 | 8/8 | II (IIa) | 82 | 71 (8–91) | 68 (83) | 11 (13) | 0 (0) | 3 (4) | 30 |
| 38–48 | 8/8§ | II (IIa) | 40 | 69 (24–91) | 31 (78) | 7 (18) | 0 (0) | 2 (5) | 25 |
| 3–23 | 2/2 | I (IVb) | 40 | 69 (1–90) | 23 (58) | 11 (28) | 6 (15) | 0 (0) | 29 |
| 43–63 | 155/155 | II (IIa) | 17 | 75 (42–95) | 15 (88) | 1 (6) | 0 (0) | 1 (6) | 41 |
| 27–20 | 6/6 | I (IVb) | 14 | 74 (57–98) | 11 (79) | 3 (21) | 0 (0) | 0 (0) | 29 |
| 25–1 | 1/1 | I (IVb) | 13 | 67 (2–83) | 6 (46) | 6 (46) | 0 (0) | 1 (8) | 23 |
| 41–43 | 9/9 | II (IIc) | 11 | 72 (53–93) | 9 (82) | 1 (9) | 0 (0) | 1 (9) | 45 |
| 22–2 | 1/1 | I (IVb) | 11 | 72 (37–90) | 5 (46) | 4 (36) | 2 (18) | 0 (0) | 11 |
| 44–61 | 155/155 | II (IIa) | 10 | 76 (49–91) | 7 (70) | 2 (20) | 1 (10) | 0 (0) | 33 |
| 71–43¶ | 9/9 | II (IIa) | 8 | 77 (44–94) | 7 (88) | 1 (13) | 0 (0) | 0 (0) | 25 |
| 67–92 | 1/1 | I (IVb) | 8 | 74 (63–98) | 7 (88) | 1 (13) | 0 (0) | 0 (0) | 25 |
| 27–18 | 6/6 | I (IVb) | 8 | 52 (50–76) | 3 (38) | 4 (50) | 1 (13) | 0 (0) | 29 |
| 12–38 | 7/7 | II (IIa) | 8 | 73 (51–90) | 3 (38) | 5 (63) | 0 (0) | 0 (0) | 13 |
| 35–26 | 59/59 | I (IIb) | 8 | 70 (55–80) | 4 (50) | 2 (25) | 2 (25) | 0 (0) | 17 |
*Data are for pulsotypes found in >8 cases. Pulsotype is for combined AscI and ApaI pattern. BSI, blood stream infection; CC, clonal complex; CFR, case-fatality rate; CNS, central nervous system; PFGE, pulsed-field gel electrophoresis; ST, sequence type.
†Calculated for non–pregnancy-associated cases only.
‡Includes peritonitis, pleuritis, arthritis, abscesses, and osteitis.
§One of the 5 representative isolates selected for multilocus sequence typing for this pulsotype was ST120/CC8.
¶Confirmed outbreak described previously (15).
1Preliminary results from this study were presented at the 18th International Symposium on Problems of Listeriosis (ISOPOL XVIII), September 19–22, 2013, Goa, India.