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Volume 22, Number 4—April 2016
Dispatch

Cross-Neutralization between Human and African Bat Mumps Viruses

Hiroshi Katoh, Toru Kubota, Toshiaki Ihara, Ken Maeda, Makoto TakedaComments to Author , and Minoru Kidokoro
Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (H. Katoh, T. Kubota, M. Takeda, M. Kidokoro); Mie Hospital, Mie, Japan (T. Ihara); Yamaguchi University, Yamaguchi, Japan (K. Maeda)

Main Article

Table

Mumps virus neutralization test for serum of healthy human adults, Japan*

Serum sample no. Patient age, y Mumps history
 EIA titer‡ NT titer†
Natural Infection Vaccinated rOdate rOdate/ABMuV-F rOdate/ABMuV-HN rOdate/ABMuV-FHN
1 32 Unknown + 22.35 121 36 133 122
2 40 Unknown – 21.36 21 38 78 109
3 49 Unknown – 22.09 26 7 31 12
4 48 + – 22.94 176 122 183 149
5 58 + – 22.80 41 31 41 33
6 56 + – 22.55 31 8 85 27
7 40 Unknown – 21.84 88 105 58 33
8 35 + – 23.32 186 60 131 118
9 33 Unknown – 22.48 83 30 81 37
10 31 + – 22.78 53 5 122 26
11 18 Unknown – 20.74 <4 <4 <4 <4
12 18 Unknown – 20.64 <4 <4 <4 <4

*ABMuV, African bat mumps virus; EIA, enzyme immunoassay; F, fusion; HN, hemagglutinin-neuraminidase; NT, neutralizing; r, recombinant; +, positive; –, negative.
†NT titer was determined as the dilution of serum that gave 50% plaque reduction compared with the average number of plaques formed in the absence of serum using the method of Reed and Muench.
‡Determined by using a commercially available indirect IgG eEIA kit (Mumps IgG-EIA kit; Denka Seiken Co., Niigata, Japan) according to the manufacturer’s instruction. Titers <21 are seronegative, 21–22 are indeterminate, and >22 are seropositive.

Main Article

Page created: March 16, 2016
Page updated: March 16, 2016
Page reviewed: March 16, 2016
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