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Volume 5, Number 5—October 1999

Research

Influence of Host Genetics on the Severity of Coccidioidomycosis

Leslie Louie*Comments to Author , Susanna Ng*, Rana Hajjeh†, Royce Johnson‡, Duc Vugia§, S. Benson Werner§, Ronald Talbot¶, and William Klitz*
Author affiliations: *University of California, Berkeley, California, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Kern Medical Center, Bakersfield, California, USA; §California Department of Health Services, Berkeley, California, USA; ¶Kern County Public Health Department, Bakersfield, California, USA

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Table 2

Hardy-Weinberg test results (p values) for HLA class II loci, by ethnicity and severity of diseasea

Cases DRB1 DQA1 DQB1 DPB1 N
Hispanic, Severe 0.34 0.18 0.38 0.27 50
Hispanic, Mild 0.12 0.11 0.002 0.045 32
Caucasian, Severe 0.09 0.14 0.38 0.008 27
Caucasian, Mild 0.12 0.14 0.11 0.022 50
African-American, Severe 0.63 0.80 0.67 0.31 2

aNumbers in bold indicate alleles not in Hardy-Weinberg equilibrium for a particular group and locus.

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