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Volume 5, Number 5—October 1999

Research

Influence of Host Genetics on the Severity of Coccidioidomycosis

Leslie Louie*Comments to Author , Susanna Ng*, Rana Hajjeh†, Royce Johnson‡, Duc Vugia§, S. Benson Werner§, Ronald Talbot¶, and William Klitz*
Author affiliations: *University of California, Berkeley, California, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Kern Medical Center, Bakersfield, California, USA; §California Department of Health Services, Berkeley, California, USA; ¶Kern County Public Health Department, Bakersfield, California, USA

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Table 4

Significance levels from contingency table analyses of allele distributions for by ethnicity and severity of coccidioidomycosis, diseasea

Ethnic group Locus. Severe vs mild Severe vs control Mild vs control
Caucasian DQA1 0.231 0.069 0.048
DQB1 0.024 0.02 0.002
DRB1 0.075 0.12 <0.001
DR-DQ 0.031 <0.001 <0.001
DPB1 0.781 0.215 0.355
Hispanics DQA1 0.074 — —
DQB1 0.41 0.003 0.16
DRB1 0.63 <0.001 0.16
DR-DQ 0.29 <0.001 0.02
DPB1 0.024 0.403 0.026
African- DQA1 — 0.89 —
Americans DQB1 — 0.34 —
DRB1 — 0.001 —
DR-DQ — <0.001 —
DPB1 — 0.38 —

aSignificant test results are in bold

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