Emerging Infectious Disease ISSN: 1080-6059

National Tuberculosis Genotyping and Surveillance Network: Analysis of the Genotype Database

Lauren S. Cowan* and Jack T. Crawford*

Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

Figure 7

Motifs used to assign spoligotype patterns to spoligotype families. Each spoligotype was analyzed for the bovis (16), africanum (17), East-African-Indian (EA-I) (13,18), X (13), Latin American-Mediterranean 1 and 2 (13,18), and Haarlem a and b spoligotype motifs (10). Each motif definition was modified from the original references to ensure that motifs were not identified in a spoligotype pattern due to an unrelated deletion at the spacers of interest; each of the motif-defining absent spacers must be flanked on both sides by the adjacent spacer. The 43 spacers in the spoligotype pattern are classified with symbols: X: spacer must be present; 0: spacer must be absent; -: spacer may or may not be present; spacers in shaded boxes: at least one of the spacers in the box must be present.

Figure 7. Motifs used to assign spoligotype patterns to spoligotype families. Each spoligotype was analyzed for the bovis (16), africanum (17), East-African-Indian (EA-I) (13,18), X (13), Latin American-Mediterranean 1 and 2 (13,18), and Haarlem a and b spoligotype motifs (10). Each motif definition was modified from the original references to ensure that motifs were not identified in a spoligotype pattern due to an unrelated deletion at the spacers of interest; each of the motif-defining absent spacers must be flanked on both sides by the adjacent spacer. The 43 spacers in the spoligotype pattern are classified with symbols: X: spacer must be present; 0: spacer must be absent; -: spacer may or may not be present; spacers in shaded boxes: at least one of the spacers in the box must be present.

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