Volume 8, Number 11—November 2002
THEME ISSUE
Tuberculosis Genotyping
Tuberculosis Genotyping Network, United States
Identifying the Sources of Tuberculosis in Young Children: A Multistate Investigation
Sumi J. Sun*
, Diane E. Bennett†, Jennifer Flood*, Ann M. Loeffler*, Steve Kammerer†, and Barbara A. Ellis†
, Diane E. Bennett†, Jennifer Flood*, Ann M. Loeffler*, Steve Kammerer†, and Barbara A. Ellis†Table 4
Characteristics of refuted and confirmed patients pairsa
| Refuted patient pairs n=8 (%) | Confirmed patient pairs n=44 (%) | |
|---|---|---|
| Characteristics of young children | ||
| Mean age, monthsb | 16 | 13 |
| Female | 4 (50) | 23 (52) |
| Race/ethnicity | ||
| Black, non-Hispanic | 5 (63) | 20 (45) |
| Hispanic | 3 (38) | 16 (36) |
| Asian | 0 (0) | 5 (11) |
| White, non-Hispanic | 0 (0) | 1 (2) |
| Native American/Alaskan Native | 0 (0) | 2 (5) |
| Foreign-born | 1 (13) | 0 (0) |
| Source patient characteristics | ||
| Mean age, yrs | 25 | 31 |
| Female | 6 (75) | 18 (41) |
| Race or ethnicity | ||
| Black, non-Hispanic | 5 (63) | 20 (45) |
| Hispanic | 3 (38) | 17 (39) |
| Asian | 0 (0) | 5 (11) |
| Native American or Alaskan Native | 0 (0) | 2 (5) |
| Foreign-born | 3 (38) | 20 (45) |
| Case patient characteristics | ||
| Shared household | 5 (63) | 32 (73) |
| Discordant drug susceptibilitiesc | 0 (0) | 3 (7) |
| Different race/ethnicity | 0 (0) | 1 (2) |
aFor tuberculosis patients <5 years of age and their suspected source patients. Refuted patient pairs are suspected patient pairs with discordant genotypes; confirmed patient pairs are suspected patient pairs with concordant genotypes.
bWilcoxon rank-sum test: p=0.03.
cExcludes two patient pairs in which the children had drug-resistant Mycobacterium tuberculosis strains (streptomycin and ethambutol resistance, respectively), but susceptibility results were not done for the identified source patient.
