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Volume 8, Number 2—February 2002


Community-Acquired Klebsiella pneumoniae Bacteremia: Global Differences in Clinical Patterns

Wen-Chien Ko*, David L. Paterson†‡, Anthanasia J. Sagnimeni‡, Dennis S. Hansen§, Anne von Gottberg¶, Sunita Mohapatra#, Jose Maria Casellas**, Herman Goossens††, Lutfiye Mulazimoglu‡‡, Gordon Trenholme#, Keith P. Klugman¶, Joseph G. McCormack‡, and Victor L. Yu†Comments to Author 
Author affiliations: *National Cheng Kung University Medical College, Taiwan; †Veterans Administration Medical Center and University of Pittsburgh, Pittsburgh, Pennsylvania, USA; ‡University of Queensland, Mater Adults Hospital, Brisbane, Australia; §Statens Serum Institut, Copenhagen, Denmark; ¶South African Institute of Medical Research, Johannesburg, South Africa; #Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois, USA; **Sanatorio San Lucas, Buenos Aires, Argentina; ††University Hospital, Antwerp, Belgium; ‡‡Marmara University, Istanbul, Turkey;

Main Article

Table 3

Comparison of the characteristics of patients with community-acquired bacteremic pneumonia due to Klebsiella pneumoniae and other patients with community-acquired K. pneumoniae bacteremia: association between pneumonia and alcoholism and residence in South Africa

Characteristic Bacteremic pneumonia
(n=57) Bacteremia without
pneumonia (n=145) p valuea
Resides in South Africa 25 (44%) 15 (10%) <0.001
Age (years) 53.6 58.6 0.07
Serum creatinineb (mg/dL) 2.1 2.3 0.2
Blood urea nitrogenb (mg/dL) 34.8 37.9 NS
Liver function testsb,c
Serum albumin (g/mL) 2.8 3.1 0.05
Serum bilirubin (mg/dL) 2.8 2.9 NS
AST (IU/mL) 174 303 NS
ALT (IU/mL) 115 189 NS
Underlying disease
Diabetes mellitus (%) 12 (21%) 53 (37%) 0.03
Alcoholism (%) 10 (18%) 6 (4%) 0.007
Malignancy (%) 7 (12%) 36 (25%) 0.05
HIV infection (%) 6 (10%) 1 (1%) 0.002
No underlying disease 23 (40%) 44 (30%) NS (0.17)
Critically ill 21 (37%) 23 (16%) 0.001
Death rate at 14 days (%) 31 (54%) 32 (22%) 0.0001

aNS = not significant at p >0.20; AST = aspartate aminotransferase; ALT = alanine aminotransferase.

bLaboratory values are those taken on first visit to a health-care provider; for continuous variables, the figures in the table are mean values.

cBacteremic patients with liver cirrhosis, acute cholangitis, and liver abscess were excluded from the analysis of liver function tests.

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1United States: Pittsburgh Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, and Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois; Taiwan: National Cheng Kung University Medical College, Tainan; Australia: Royal Brisbane Hospital, Mater Adults Hospital, and Greenslopes Private Hospital, all in Brisbane; South Africa: Hillbrow Hospital and Baragwanath Hospital, both in Johannesburg; Turkey: Marmara University Hospital, Istanbul; Belgium: University Hospital, Antwerp; and Argentina: San Lucas Hospital and Comunidad Olivos Hospital, both in Buenos Aires.

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