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Volume 8, Number 3—March 2002

Research

Immunization with Heterologous Flaviviruses Protective Against Fatal West Nile Encephalitis

Robert B. TeshComments to Author , Amelia P.A. Travassos da Rosa, Hilda Guzman, Tais P. Araujo, and Shu-Yuan Xiao
Author affiliations: University of Texas Medical Branch, Galveston, Texas, USA;

Main Article

Table 1

Pattern of viremia and hemagglutination inhibition (HI) antibody response in 10 adult Flavivirus-naïve (control) hamsters, following intraperitoneal inoculation of 104 TCID50 of West Nile virus (WNV)

Animal No. Day postinoculation
D-1 D-2 D-3 D-4 D-5 D-6
8001 4.3a(0) 5.0 (0) 5.0 (0) 3.3 (0) 1.0 (1:80) 1.0 (1:320)
8002 4.7 (0) 5.5 (0) 5.2 (0) 3.5 (0) 2.5 (1:40) 0 (1:320)
8003 5.3 (0) 5.3 (0) 5.0 (0) 3.5 (0) 2.5 (1:40) 0 (1:320)
8004 2.0 (0) 5.0 (0) 5.0 (0) 4.3 (0) 2.5 (1:40) 1.0 (1:160)
8005 4.0 (0) 5.0 (0) 5.5 (0) 3.7 (0) 1.7 (1:80) 1.0 (1:320)
8006 4.6 (0) 5.2 (0) 5.7 (0) 4.3 (0) 2.7 (1:80) 0 (1:320)
8007 4.3 (0) 5.7 (0) 4.6 (0) 4.0 (0) 2.0 (1:80) 1.0 (1:320)
8008 4.2 (0) 5.8 (0) 4.8 (0) 1.8 (0) 2.0 (1:80) 0 (1:320)
8009 5.2 (0) 5.2 (0) 5.0 (0) 3.2 (0) 2.8 (1:80) 0 (1:320)
8010 4.7 (0) 4.7 (0) 5.5 (0) 3.5 (0) 1.8 (1:80) 0.7 (1:320)
Mean 4.3 5.2 5.1 3.5 2.1 0.5
SD 0.92 0.34 0.34 0.71 0.54 0.50

aWNV titer expressed as log10 TCID50/mL of blood. 0 <0.7. (HI antibody titer; 0 <1:20)

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