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Volume 9, Number 12—December 2003

Research

Global Distribution of Rubella Virus Genotypes

Du-Ping Zheng*1, Teryl K. Frey*Comments to Author , Joseph Icenogle†, Shigetaka Katow†‡, Emily S. Abernathy*†, Ki-Joon Song§, Wen-Bo Xu¶, Vitaly Yarulin#, R.G. Desjatskova#, Yair Aboudy**, Gisela Enders††, and Margaret Croxson‡‡
Author affiliations: *Georgia State University, Atlanta, Georgia, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡National Institute of Infectious Diseases, Tokyo, Japan; §Korea University, Seoul, Korea; ¶Chinese Centers for Disease Control and Prevention, Beijing, China; #Institute of Viral Preparations, Moscow, Russia; **Chaim Sheba Medical Center, Tel-Hashomer, Israel; ††Institute for Virology, Infectiology and Epidemiology, Stuttgart, Germany; ‡‡Auckland Hospital, Auckland, New Zealand

Main Article

Table 3

Comparison of genotypic statistics using the E1 gene and the molecular epidemiology window (MEW)

Window G+C contenta Transition/transversiona Intergenotypic distancea,b
Intragenotypic distancesa,c
Range Mean Mean RGI vs RGII RGI
RGII
Range Mean Range Mean
E1
66.6
6.34
0.08~10.32
4.92
7.28
0.08~5.75
3.55
0~7.95
5.66
MEW 66.1 6.15 0~11.69 4.97 8.32 0~5.97 3.49 0~8.71 6.61

aStatistics were determined from all sequences listed in Table 1.
bThe range and mean of genetic distances (% difference) were determined by using all sequences. The mean rubella genotype I (RGI) vs. RGII was determined from all of the pairwise RGI-RGII combinations.
cThe range and mean of genetic distances were determined for RGI and RGII viruses separately.

Main Article

1Current address: Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

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