Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 9, Number 4—April 2003


Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model

L. Temime*Comments to Author , P.Y. Boëlle*, P. Courvalin†, and D. Guillemot†
Author affiliations: *Institute National de la Santé et de la Recherdhé, Paris, France; †Unité des Agents Antibactériens, Institut Pasteur, Paris, France

Main Article

Table 1

Model parameters and their values (8,21)

Parameters (at MIC m) Pneumococci Meningococci
Treatment duration 1/γ 8 d 8 d
Weighted frequency of treatment α 1 / 2 y 1 / 3 y
Refractory phase duration 1/θ 2 wk 2 wk
Carriage duration 1/λ 2.2 mo 10 mo
Time before antibiotic action 1/ν 4 d 4 d
Contact rate (absence of treatment) β 0.23 wk-1person-1 0.026 wk-1person-1
Contact rate (presence of treatment) β´(m) formula image formula image
Nondecolonization probability after treatment σ (m) formula image formula image
MIC increase after a genetic event F (m) Randomly selected from a seminormal law

Main Article

Top of Page The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO