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Volume 12, Number 1—January 2006

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Volume 12, Number 1—January 2006

Painting Nature on the Wing - PDF Version

"The Sun will not rise, or set, without my notice, and thanks," wrote Winslow Homer to his brother Charles... more



J. K. Taubenberger and D. M. Morens
R. G. Webster et al.
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Highly pathogenic H5N1 influenza viruses continue to evolve and increase their geographic and host range.


E. D. Kilbourne
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Influenza A virus infection created confusion in distinguishing true pandemics, pseudopandemics, and epidemics.

J. C. Gaydos et al.
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Published literature and events surrounding the outbreak are reviewed.

D. J. Sencer and J. Millar
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The swine flu vaccination program has implications for the current pandemic preparedness.

W. R. Dowdle
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Conditions that lead to influenza pandemics are not fully understood.

R. Krause
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Knowledge of the 1976 swine flu episode can help shape public health response to future pandemic threats.

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A. García-Sastre
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The regulatory activities of the nonstructural protein 1 appear to affect the ability of influenza viruses to infect multiple animal species.

P. G. Thomas et al.
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Cell-mediated immune responses should be considered in vaccination protocols.


A. S. Monto
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Controlling a pandemic with vaccine and antiviral drugs will require a coordinated international approach to determine how the least amount of virus can immunize the largest segment of a population.

P. Palese
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Better influenza vaccines are possible and necessary.

C. J. Luke and K. Subbarao
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A program to develop vaccines to prevent avian influenza pandemics is under way.Vaccines for Pandemic Influenza

A. S. Fauci
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New vaccine technologies and antiviral drugs are needed to prepare for the next influenza pandemic.

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Volume 12, Number 1—January 2006 - Continued


V. J. Lee et al.
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Stockpiling drugs to prevent and treat influenza would be economically effective.

C. G. Grijalva et al.
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Two surveillance systems gave a better estimate of influenza hospitalizations in children <5 years of age than either system alone.

S. Cauchemez et al.
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A statistical method can be used for early monitoring of the effect of disease control measures.

A. Chow et al.
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Surveillance and annual vaccination are needed for at-risk populations in tropical countries.

Y. Hsieh and Y. Cheng
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The multistage Richards model provides insights into ongoing outbreaks that may be useful for real-time public health responses.

M. Kaye et al.
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Virus can replicate in several common cell lines, sometimes without cytopathic effect.

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Policy Review

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Closing international borders was usually ineffective in past pandemics and would be less effective today.

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Recommended interventions vary by transmission pattern, pandemic phase, and disease severity.

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H5N1 Outbreaks and Enzootic Influenza

p. 6

Influenza and the Origins of The Phillips Collection, Washington, DC

p. 78

Ocular Vaccinia Infection in Laboratory Worker, Philadelphia, 2004

p. 134

Rickettsia felis infection, Tunisia

p. 139

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