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Clinical Update
Yellow Fever Vaccine Shortage

The manufacturer of yellow fever vaccine (YF-Vax), Sanofi Pasteur (Swiftwater, PA), has informed CDC that the supply of YF-Vax (the only yellow fever vaccine available in the United States) is currently limited. As a result, the manufacturer has placed limits on orders of the single-dose and 5-dose vials of YF-Vax. These ordering limits are expected to be in place until April 2014.

According to the manufacturer’s package insert, all YF-Vax must be used within 1 hour of reconstitution (both single-dose and 5-dose vials). Clinics using the 5-dose vials are advised to schedule patients to efficiently use the available vaccine doses within this 1-hour timeframe.

Health care providers should refer to the section titled Travel Vaccines and Malaria Information, by Country in CDC Health Information for International Travel 2014 (the “Yellow Book”) for information about which countries require yellow fever vaccination for entry and for which countries CDC recommends yellow fever vaccination. In the absence of a country requirement, CDC does not recommend yellow fever vaccination if the traveler's itinerary does not include travel to a yellow fever–endemic area.

For further information, contact Sanofi Pasteur customer service at 1-800-VACCINE (1-800-822-2463).


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