Volume 14, Number 11—November 2008
Dispatch
Phylogenetics and Pathogenesis of Early Avian Influenza Viruses (H5N1), Nigeria
Comfort O. Aiki-Raji1, Patricia V. Aguilar1, Yong-Kuk Kwon, Sue Goetz, David L. Suarez, Aashish I. Jethra, Oyekanmi Nash, Christopher A.O. Adeyefa, Festus D. Adu, David Swayne, and Christopher F. Basler
Table
Virus isolation titers from chickens inoculated with highly pathogenic influenza A/chicken/Nigeria/228-5/2005 (H5N1) and controls*
| Sample |
Virus-positive swabs/swabs tested,
no. (mean titer† as log10 EID50/mL) |
Virus-positive tissues/tissues tested, no. (mean titer† as log10 EID50/g) |
||||||
|---|---|---|---|---|---|---|---|---|
| Oropharyngeal |
Tracheal |
Heart |
Kidney |
Lung |
Muscle |
Brain |
||
| Sham | 0/2 | 0/2 | 0/2 | 0/2 | 0/2 | 0/2 | 0/2 | |
| Experimental | ||||||||
| 1 dpi | 2/2 (2.4) | 1/2 (1.7) | 1/2 (2.9) | 1/2 (4.5) | 1/2 (4.9) | 1/2(3.9) | 1/2 (3.5) | |
| 2 dpi | 2/2 (6.1) | 2/2 (6.8) | 2/2 (8.7) | 2/2 (7.9) | 2/2 (7.6) | 2/2 (6.8) | 2/2 (5.6) | |
*Virus isolated from tissues and swabs sample on 1 and 2 days postinoculation (dpi). EID50, mean embryo infectious doses.
†Limit of detection <101.9 EID50/g of tissue or <100.9 EID50/mL sample.
